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TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.
Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY. Rousseaux MW, et al. Among authors: park j. Elife. 2016 Oct 25;5:e19809. doi: 10.7554/eLife.19809. Elife. 2016. PMID: 27779468 Free PMC article.
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JSC, Orr HT, Westbrook TF, Botas J, Zoghbi HY. Park J, et al. Nature. 2013 Jun 20;498(7454):325-331. doi: 10.1038/nature12204. Epub 2013 May 29. Nature. 2013. PMID: 23719381 Free PMC article.
A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.
Lasagna-Reeves CA, Rousseaux MW, Guerrero-Muñoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY. Lasagna-Reeves CA, et al. Among authors: park j. Elife. 2015 May 19;4:e07558. doi: 10.7554/eLife.07558. Elife. 2015. PMID: 25988806 Free PMC article.
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.
Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY. Lasagna-Reeves CA, et al. Among authors: park j. Neuron. 2016 Oct 19;92(2):407-418. doi: 10.1016/j.neuron.2016.09.022. Epub 2016 Oct 6. Neuron. 2016. PMID: 27720485 Free PMC article.
Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models.
Tan Q, Yalamanchili HK, Park J, De Maio A, Lu HC, Wan YW, White JJ, Bondar VV, Sayegh LS, Liu X, Gao Y, Sillitoe RV, Orr HT, Liu Z, Zoghbi HY. Tan Q, et al. Among authors: park j. Hum Mol Genet. 2016 Dec 1;25(23):5083-5093. doi: 10.1093/hmg/ddw337. Hum Mol Genet. 2016. PMID: 28007900 Free PMC article.
Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease-linked MATR3 mutations in Drosophila.
Zhao M, Kao CS, Arndt C, Tran DD, Cho WI, Maksimovic K, Chen XXL, Khan M, Zhu H, Qiao J, Peng K, Hong J, Xu J, Kim D, Kim JR, Lee J, van Bruggen R, Yoon WH, Park J. Zhao M, et al. Among authors: park j. FEBS Lett. 2020 Sep;594(17):2800-2818. doi: 10.1002/1873-3468.13858. Epub 2020 Jun 28. FEBS Lett. 2020. PMID: 32515490 Free article.
RNA-Binding Proteins in Amyotrophic Lateral Sclerosis.
Zhao M, Kim JR, van Bruggen R, Park J. Zhao M, et al. Among authors: park j. Mol Cells. 2018 Sep 30;41(9):818-829. doi: 10.14348/molcells.2018.0243. Epub 2018 Aug 29. Mol Cells. 2018. PMID: 30157547 Free PMC article. Review.
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