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Evaluation of CLSI M44-A2 disk diffusion and associated breakpoint testing of caspofungin and micafungin using a well-characterized panel of wild-type and fks hot spot mutant Candida isolates.
Arendrup MC, Park S, Brown S, Pfaller M, Perlin DS. Arendrup MC, et al. Antimicrob Agents Chemother. 2011 May;55(5):1891-5. doi: 10.1128/AAC.01373-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357293 Free PMC article.
However, the numbers of fks hot spot mutant isolates misclassified as being susceptible (S) (very major errors [VMEs]) were high (61% for caspofungin [S, ≥11 mm] and 93% for micafungin [S, ≥14 mm]). Changing the disk diffusion breakpoint to S at ≥22 mm …
However, the numbers of fks hot spot mutant isolates misclassified as being susceptible (S) (very major errors [VMEs]) were high (61% …
Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints.
Garcia-Effron G, Park S, Perlin DS. Garcia-Effron G, et al. Antimicrob Agents Chemother. 2009 Jan;53(1):112-22. doi: 10.1128/AAC.01162-08. Epub 2008 Oct 27. Antimicrob Agents Chemother. 2009. PMID: 18955538 Free PMC article.
A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility.
Garcia-Effron G, Katiyar SK, Park S, Edlind TD, Perlin DS. Garcia-Effron G, et al. Antimicrob Agents Chemother. 2008 Jul;52(7):2305-12. doi: 10.1128/AAC.00262-08. Epub 2008 Apr 28. Antimicrob Agents Chemother. 2008. PMID: 18443110 Free PMC article.
Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase.
Kahn JN, Garcia-Effron G, Hsu MJ, Park S, Marr KA, Perlin DS. Kahn JN, et al. Antimicrob Agents Chemother. 2007 May;51(5):1876-8. doi: 10.1128/AAC.00067-07. Epub 2007 Feb 26. Antimicrob Agents Chemother. 2007. PMID: 17325225 Free PMC article.
Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis.
Laverdière M, Lalonde RG, Baril JG, Sheppard DC, Park S, Perlin DS. Laverdière M, et al. J Antimicrob Chemother. 2006 Apr;57(4):705-8. doi: 10.1093/jac/dkl022. Epub 2006 Feb 7. J Antimicrob Chemother. 2006. PMID: 16464893
Caspofungin uptake is mediated by a high-affinity transporter in Candida albicans.
Paderu P, Park S, Perlin DS. Paderu P, et al. Antimicrob Agents Chemother. 2004 Oct;48(10):3845-9. doi: 10.1128/AAC.48.10.3845-3849.2004. Antimicrob Agents Chemother. 2004. PMID: 15388444 Free PMC article.
Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint.
Garcia-Effron G, Lee S, Park S, Cleary JD, Perlin DS. Garcia-Effron G, et al. Antimicrob Agents Chemother. 2009 Sep;53(9):3690-9. doi: 10.1128/AAC.00443-09. Epub 2009 Jun 22. Antimicrob Agents Chemother. 2009. PMID: 19546367 Free PMC article.
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