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308 results
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Validation of a novel molecular orbital approach (COMPACT) for the prospective safety evaluation of chemicals, by comparison with rodent carcinogenicity and Salmonella mutagenicity data evaluated by the U.S. NCI/NTP.
Lewis DF, Ioannides C, Parke DV. Lewis DF, et al. Among authors: parke dv. Mutat Res. 1993 Feb;291(1):61-77. doi: 10.1016/0165-1161(93)90018-u. Mutat Res. 1993. PMID: 7678916
Chemical toxicity and reactive oxygen species.
Parke DV, Sapota A. Parke DV, et al. Int J Occup Med Environ Health. 1996;9(4):331-40. Int J Occup Med Environ Health. 1996. PMID: 9117192 Review.
A quantitative structure-activity relationship (QSAR) study of mutagenicity in several series of organic chemicals likely to be activated by cytochrome P450 enzymes.
Lewis DF, Ioannides C, Parke DV. Lewis DF, et al. Among authors: parke dv. Teratog Carcinog Mutagen. 2003;Suppl 1:187-93. doi: 10.1002/tcm.10073. Teratog Carcinog Mutagen. 2003. PMID: 12616608
Metal toxicity in two rodent species and redox potential: Evaluation of quantitative structure-activity relationships.
Lewis DFV, Dobrota M, Taylor MG, Parke DV. Lewis DFV, et al. Among authors: parke dv. Environ Toxicol Chem. 1999 Oct;18(10):2199-2204. doi: 10.1002/etc.5620181012. Environ Toxicol Chem. 1999. PMID: 29857628
The Scheele memorial lecture 1989. Drug metabolism in the design and safety evaluation of new drugs.
Parke DV. Parke DV. Acta Pharm Nord. 1990;2(4):231-48. Acta Pharm Nord. 1990. PMID: 2257083 Review. No abstract available.
Computer modelling and in vitro tests in the safety evaluation of chemicals-Strategic applications.
Parke DV, Ioannides C, Lewis DF. Parke DV, et al. Toxicol In Vitro. 1990;4(4-5):680-5. doi: 10.1016/0887-2333(90)90141-f. Toxicol In Vitro. 1990. PMID: 20702255
The cytochromes P450 and mechanisms of chemical carcinogenesis.
Parke DV. Parke DV. Environ Health Perspect. 1994 Oct;102(10):852-3. doi: 10.1289/ehp.94102852. Environ Health Perspect. 1994. PMID: 9644192 Free PMC article. Review.
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.
Lewis DF, Ioannides C, Parke DV. Lewis DF, et al. Among authors: parke dv. Environ Health Perspect. 1998 Oct;106(10):633-41. doi: 10.1289/ehp.98106633. Environ Health Perspect. 1998. PMID: 9755138 Free PMC article. Review.
A combined COMPACT and HazardExpert study of 40 chemicals for which information on mutagenicity and carcinogenicity is known, including the results of human epidemiological studies.
Lewis DF, Ioannides C, Parke DV. Lewis DF, et al. Among authors: parke dv. Hum Exp Toxicol. 1998 Oct;17(10):577-86. doi: 10.1177/096032719801701009. Hum Exp Toxicol. 1998. PMID: 9821022
Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicals.
Lewis DF, Ioannides C, Parke DV. Lewis DF, et al. Among authors: parke dv. Mutat Res. 1998 Jan 13;412(1):41-54. doi: 10.1016/s1383-5718(97)00145-9. Mutat Res. 1998. PMID: 9508363
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