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A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses.
Markert JM, Razdan SN, Kuo HC, Cantor A, Knoll A, Karrasch M, Nabors LB, Markiewicz M, Agee BS, Coleman JM, Lakeman AD, Palmer CA, Parker JN, Whitley RJ, Weichselbaum RR, Fiveash JB, Gillespie GY. Markert JM, et al. Among authors: parker jn. Mol Ther. 2014 May;22(5):1048-55. doi: 10.1038/mt.2014.22. Epub 2014 Feb 27. Mol Ther. 2014. PMID: 24572293 Free PMC article. Clinical Trial.
Oncolytic viral therapy of malignant glioma.
Parker JN, Bauer DF, Cody JJ, Markert JM. Parker JN, et al. Neurotherapeutics. 2009 Jul;6(3):558-69. doi: 10.1016/j.nurt.2009.04.011. Neurotherapeutics. 2009. PMID: 19560745 Free PMC article. Review.
Serial passage through human glioma xenografts selects for a Deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors.
Shah AC, Price KH, Parker JN, Samuel SL, Meleth S, Cassady KA, Gillespie GY, Whitley RJ, Markert JM. Shah AC, et al. Among authors: parker jn. J Virol. 2006 Aug;80(15):7308-15. doi: 10.1128/JVI.00725-06. J Virol. 2006. PMID: 16840311 Free PMC article.
Oncolytic HSV-1 for the treatment of brain tumours.
Markert JM, Parker JN, Buchsbaum DJ, Grizzle WE, Gillespie GY, Whitley RJ. Markert JM, et al. Among authors: parker jn. Herpes. 2006 Nov;13(3):66-71. Herpes. 2006. PMID: 17147910 Review.
46 results