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Stem Cell Therapy for Parkinson's Disease: A Mechanistically Distinct Role for Muse Cells.
Mesches MH, Granholm AC, Paredes D, Mesches K, Oguma Y, Dezawa M. Mesches MH, et al. Among authors: paredes d. J Clin Med. 2026 Jun 5;15(11):4370. doi: 10.3390/jcm15114370. J Clin Med. 2026. PMID: 42279231 Free PMC article. Review.
Cell replacement therapy is a promising investigational approach for Parkinson's disease (PD), a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. Although current PD therapies provide symptomatic re …
Cell replacement therapy is a promising investigational approach for Parkinson's disease (PD), a neurodegenerative diso …
Foldamers rescue synucleinopathy phenotypes in multiple in vitro and in vivo models.
Dohoney RA, Palanikumar L, Oldani E, Baysah CZ, Joseph JA, Polanco D, Santos-Otte P, Stillman NH, Corcoran P, Ball TD, Fitch TC, Ahmed J, Ogbonna-Ukuku I, Reynolds Caicedo KM, Liu Y, Leehey MA, Linseman DA, Paredes DA, Birol M, Cremades N, Magzoub M, Kumar S. Dohoney RA, et al. Among authors: paredes da. Sci Transl Med. 2026 Apr;18(843):eadu1050. doi: 10.1126/scitranslmed.adu1050. Epub 2026 Apr 1. Sci Transl Med. 2026. PMID: 41920967 Free PMC article.
Synucleinopathies is an umbrella term for multiple neurological disorders, including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). A central pathological hallmark of synucleinopathies is the aggregation of alpha-synucl …
Synucleinopathies is an umbrella term for multiple neurological disorders, including Parkinson's disease (PD), Lewy bod …
Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.
Ahmed J, Fitch TC, Donnelly CM, Joseph JA, Ball TD, Bassil MM, Son A, Zhang C, Ledreux A, Horowitz S, Qin Y, Paredes D, Kumar S. Ahmed J, et al. Among authors: paredes d. Nat Commun. 2022 Apr 27;13(1):2273. doi: 10.1038/s41467-022-29724-4. Nat Commun. 2022. PMID: 35477706 Free PMC article.
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there is no successful prevention or intervention. ...
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there is no successful prevention or int …
Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit.
Gonzalez-Reyes LE, Verbitsky M, Blesa J, Jackson-Lewis V, Paredes D, Tillack K, Phani S, Kramer ER, Przedborski S, Kottmann AH. Gonzalez-Reyes LE, et al. Among authors: paredes d. Neuron. 2012 Jul 26;75(2):306-19. doi: 10.1016/j.neuron.2012.05.018. Neuron. 2012. PMID: 22841315 Free PMC article.
We report that the interruption of a non cell-autonomous mode of sonic hedgehog (Shh) signaling originating from dopaminergic neurons causes progressive, adult-onset degeneration of dopaminergic, cholinergic, and fast spiking GABAergic neurons of the mesostriatal circuit, imbalan …
We report that the interruption of a non cell-autonomous mode of sonic hedgehog (Shh) signaling originating from dopaminergic neurons causes …
Rapid differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor.
Saporta S, Willing AE, Shamekh R, Bickford P, Paredes D, Cameron DF; New Collective Author. Saporta S, et al. Among authors: paredes d. Brain Res Bull. 2004 Dec 15;64(4):347-56. doi: 10.1016/j.brainresbull.2004.09.003. Brain Res Bull. 2004. PMID: 15561470
Cell replacement therapy is of great interest as a long-term treatment of neurodegenerative diseases such as Parkinson's disease (PD). We have previously shown that Sertoli cells (SC) provide neurotrophic support to transplants of dopaminergic fetal neurons a …
Cell replacement therapy is of great interest as a long-term treatment of neurodegenerative diseases such as Parkinson's di …