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Page 1
Herbal Interventions in Parkinson's Disease: A Systematic Review of Preclinical Studies.
Zhao W, Cui H, Liu J, Sun H, Zhang Z, Zhang Z, Ma D. Zhao W, et al. Cell Mol Neurobiol. 2025 May 23;45(1):50. doi: 10.1007/s10571-025-01556-y. Cell Mol Neurobiol. 2025. PMID: 40410612 Review.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra of the midbrain. ...It highlights the therapeutic potential of TCM active ingredients …
Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the progressive degener …
Application of IVDr NMR spectroscopy to stratify Parkinson's disease with absolute quantitation of blood serum metabolites and lipoproteins.
Berezhnoy G, Bae G, Wüst L, Schulte C, Cannet C, Wurster I, Zimmermann M, Jäck A, Spruth EJ, Hellmann-Regen J, Roeske S, Pürner D, Glanz W, Maass F, Hufschmidt F, Kilimann I, Dinter E, Kimmich O, Gamez A, Levin J, Priller J, Peters O, Wagner M, Storch A, Lingor P, Düzel E, van Riesen C, Wüllner U, Teipel S, Falkenburger B, Bähr M, Zerr I, Petzold GC, Spottke A, Rizzu P, Brosseron F, Schäfer H, Gasser T, Trautwein C. Berezhnoy G, et al. Sci Rep. 2025 May 22;15(1):17738. doi: 10.1038/s41598-025-01352-0. Sci Rep. 2025. PMID: 40404791 Free article.
The challenge of early detection and stratification in Parkinson's disease (PD) is urgent due to the current emergence of mechanism-based disease-modifying treatments. ...Uni- and multivariate statistics were used to identify metabolism-driven changes …
The challenge of early detection and stratification in Parkinson's disease (PD) is urgent due to the current emergence …
Targeting Bacterial and Human Levodopa Decarboxylases for Improved Drug Treatment of Parkinson's Disease: Discovery and Characterization of New Inhibitors.
Reunanen S, Ghemtio L, Patel JZ, Patel DR, Airavaara K, Yli-Kauhaluoma J, Jeltsch M, Xhaard H, Piepponen P, Tammela P. Reunanen S, et al. Eur J Pharm Sci. 2025 May 20:107133. doi: 10.1016/j.ejps.2025.107133. Online ahead of print. Eur J Pharm Sci. 2025. PMID: 40403986
Parkinson's disease (PD) is a common neurodegenerative disease, typically treated with levodopa, which alleviates the motor symptoms of the disease. ...
Parkinson's disease (PD) is a common neurodegenerative disease, typically treated with levodopa, which alleviate …
Second brain: reviewing the gut microbiome's role in lifestyle diseases.
Ray H, Khatum J, Haldar S, Bhowmik P. Ray H, et al. BioTechnologia (Pozn). 2025 Mar 31;106(1):103-122. doi: 10.5114/bta/195495. eCollection 2025. BioTechnologia (Pozn). 2025. PMID: 40401130 Free PMC article. Review.
Lifestyle factors such as diet, mental health, stress, exercise, and others significantly influence the composition of the gut microbiome. Imbalances in this composition, termed "dysbiosis," have been linked to a wide range of diseases, including cancer, cardiovascular dis …
Lifestyle factors such as diet, mental health, stress, exercise, and others significantly influence the composition of the gut microbiome …
Autophagic dysregulation triggers innate immune activation in glucocerebrosidase deficiency.
Atilano ML, Hull AJ, Kinghorn KJ. Atilano ML, et al. Autophagy Rep. 2024 Jul 8;3(1):2372997. doi: 10.1080/27694127.2024.2372997. eCollection 2024. Autophagy Rep. 2024. PMID: 40395517 Free PMC article.
The gut-brain axis is increasingly being implicated in disease pathology, and accordingly, we demonstrated gastrointestinal dysfunction and gut microbiome dysbiosis in GD flies. ...Our research suggests that autophagic impairment in GD flies drives microbiome …
The gut-brain axis is increasingly being implicated in disease pathology, and accordingly, we demonstrated gastrointestinal dysfuncti …
The relationship between gut microbiome and human diseases: mechanisms, predisposing factors and potential intervention.
Shabani M, Ghoshehy A, Mottaghi AM, Chegini Z, Kerami A, Shariati A, Taati Moghadam M. Shabani M, et al. Front Cell Infect Microbiol. 2025 May 6;15:1516010. doi: 10.3389/fcimb.2025.1516010. eCollection 2025. Front Cell Infect Microbiol. 2025. PMID: 40395507 Free PMC article. Review.
The gut microbiome profoundly impacts various human diseases, encompassing gastrointestinal disorders, metabolic disorders, neurological disorders, and immune-related diseases. ...Furthermore, the gut-brain axis highlights the correlation between gut …
The gut microbiome profoundly impacts various human diseases, encompassing gastrointestinal disorders, metabolic disorders …
The gut-brain axis in early Parkinson's disease: from prodrome to prevention.
Oliver PJ, Civitelli L, Hu MT. Oliver PJ, et al. J Neurol. 2025 May 21;272(6):413. doi: 10.1007/s00415-025-13138-5. J Neurol. 2025. PMID: 40394204 Free PMC article. Review.
Parkinson's disease is the second most common neurodegenerative disorder and fastest growing neurological condition worldwide, yet its etiology and progression remain poorly understood. ...Crucially, gut-based interventions offer an avenue to treat Parkins …
Parkinson's disease is the second most common neurodegenerative disorder and fastest growing neurological condition wor …
Neuroprotective Effects of Paeonia lactiflora Through the Regulation of Gut Dubosiella in an MPTP-Induced Parkinson's Disease Mouse Model.
Shao X, Li M, Shi S, Wu T, Zhang Y, Guo S, Lin H, Qi X. Shao X, et al. Am J Chin Med. 2025;53(3):833-862. doi: 10.1142/S0192415X25500314. Am J Chin Med. 2025. PMID: 40374370
Emerging evidence suggests that changes in the composition of the gut microbiota may play an important role in the pathogenesis of Parkinson's disease (PD). Paeonia lactiflora Pall., a traditional Chinese medicinal herb belonging to the genus Paeonia, …
Emerging evidence suggests that changes in the composition of the gut microbiota may play an important role in the pathogenesis of …
Demyelination in psychiatric and neurological disorders: Mechanisms, clinical impact, and novel therapeutic strategies.
Murayama R, Cai Y, Nakamura H, Hashimoto K. Murayama R, et al. Neurosci Biobehav Rev. 2025 May 12;174:106209. doi: 10.1016/j.neubiorev.2025.106209. Online ahead of print. Neurosci Biobehav Rev. 2025. PMID: 40368261 Free article. Review.
Demyelination, defined as the loss of myelin sheaths around neuronal axons, is increasingly recognized as a key factor in a broad range of psychiatric and neurological disorders, including schizophrenia, major depressive disorder, bipolar disorder, post-traumatic stress di …
Demyelination, defined as the loss of myelin sheaths around neuronal axons, is increasingly recognized as a key factor in a broad range of p …
Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson's disease mice via the GLP-1/PGC-1alpha pathway.
Qi Y, Xie S, Chen J, Zhang C, Ma X, Yu Y, Yu X, Wang Y. Qi Y, et al. J Nutr Biochem. 2025 May 12:109954. doi: 10.1016/j.jnutbio.2025.109954. Online ahead of print. J Nutr Biochem. 2025. PMID: 40368220
Motor dysfunction constitutes a prominent characteristic of Parkinson's disease (PD), a neurodegenerative disorder associated with compromised mitochondrial activity, perturbed gut microbial composition, and neuronal loss. ...Its mechanism is closely related …
Motor dysfunction constitutes a prominent characteristic of Parkinson's disease (PD), a neurodegenerative disorder asso …
1,797 results