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Potential biomarkers for persistent and neuropathic pain therapy.
Sisignano M, Lötsch J, Parnham MJ, Geisslinger G. Sisignano M, et al. Among authors: parnham mj. Pharmacol Ther. 2019 Jul;199:16-29. doi: 10.1016/j.pharmthera.2019.02.004. Epub 2019 Feb 10. Pharmacol Ther. 2019. PMID: 30759376 Review.
Drugging the pain epigenome.
Niederberger E, Resch E, Parnham MJ, Geisslinger G. Niederberger E, et al. Among authors: parnham mj. Nat Rev Neurol. 2017 Jul;13(7):434-447. doi: 10.1038/nrneurol.2017.68. Epub 2017 May 26. Nat Rev Neurol. 2017. PMID: 28548108 Review.
Pharmacokinetics of non-intravenous formulations of fentanyl.
Lötsch J, Walter C, Parnham MJ, Oertel BG, Geisslinger G. Lötsch J, et al. Among authors: parnham mj. Clin Pharmacokinet. 2013 Jan;52(1):23-36. doi: 10.1007/s40262-012-0016-7. Clin Pharmacokinet. 2013. PMID: 23100195 Review.
Novel Approaches to Persistent Pain Therapy.
Sisignano M, Parnham MJ, Geisslinger G. Sisignano M, et al. Among authors: parnham mj. Trends Pharmacol Sci. 2019 Jun;40(6):367-377. doi: 10.1016/j.tips.2019.04.003. Epub 2019 May 8. Trends Pharmacol Sci. 2019. PMID: 31078322 Review.
Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab.
Mojtahed Poor S, Ulshöfer T, Gabriel LA, Henke M, Köhm M, Behrens F, Geisslinger G, Parnham MJ, Burkhardt H, Schiffmann S. Mojtahed Poor S, et al. Among authors: parnham mj. Clin Exp Immunol. 2019 May;196(2):259-275. doi: 10.1111/cei.13261. Epub 2019 Feb 3. Clin Exp Immunol. 2019. PMID: 30656642 Free PMC article.
Ceramides as Novel Disease Biomarkers.
Kurz J, Parnham MJ, Geisslinger G, Schiffmann S. Kurz J, et al. Among authors: parnham mj. Trends Mol Med. 2019 Jan;25(1):20-32. doi: 10.1016/j.molmed.2018.10.009. Epub 2018 Nov 23. Trends Mol Med. 2019. PMID: 30477968 Review.
An in vitro test system for compounds that modulate human inflammatory macrophage polarization.
Shiratori H, Feinweber C, Luckhardt S, Wallner N, Geisslinger G, Weigert A, Parnham MJ. Shiratori H, et al. Among authors: parnham mj. Eur J Pharmacol. 2018 Aug 15;833:328-338. doi: 10.1016/j.ejphar.2018.06.017. Epub 2018 Jun 18. Eur J Pharmacol. 2018. PMID: 29920284
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G. Sisignano M, et al. Among authors: parnham mj. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. doi: 10.1073/pnas.1613246113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791151 Free PMC article.
Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.
Maucher IV, Rühl M, Kretschmer SB, Hofmann B, Kühn B, Fettel J, Vogel A, Flügel KT, Manolikakes G, Hellmuth N, Häfner AK, Golghalyani V, Ball AK, Piesche M, Matrone C, Geisslinger G, Parnham MJ, Karas M, Steinhilber D, Roos J, Maier TJ. Maucher IV, et al. Among authors: parnham mj. Biochem Pharmacol. 2017 Feb 1;125:55-74. doi: 10.1016/j.bcp.2016.11.004. Epub 2016 Nov 4. Biochem Pharmacol. 2017. PMID: 27823964
Drug Repurposing for the Development of Novel Analgesics.
Sisignano M, Parnham MJ, Geisslinger G. Sisignano M, et al. Among authors: parnham mj. Trends Pharmacol Sci. 2016 Mar;37(3):172-183. doi: 10.1016/j.tips.2015.11.006. Epub 2015 Dec 17. Trends Pharmacol Sci. 2016. PMID: 26706620
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