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Clinical implications and utility of field cancerization.
Dakubo GD, Jakupciak JP, Birch-Machin MA, Parr RL. Dakubo GD, et al. Cancer Cell Int. 2007 Mar 15;7:2. doi: 10.1186/1475-2867-7-2. Cancer Cell Int. 2007. PMID: 17362521 Free PMC article.
Paired ductal carcinoma in situ and invasive breast cancer lesions in the D-loop of the mitochondrial genome indicate a cancerization field effect.
Maggrah A, Robinson K, Creed J, Wittock R, Gehman K, Gehman T, Brown H, Harbottle A, Froberg MK, Klein D, Reguly B, Parr R. Maggrah A, et al. Biomed Res Int. 2013;2013:379438. doi: 10.1155/2013/379438. Epub 2012 Dec 26. Biomed Res Int. 2013. PMID: 23509716 Free PMC article.
Accurate prediction of repeat prostate biopsy outcomes by a mitochondrial DNA deletion assay.
Robinson K, Creed J, Reguly B, Powell C, Wittock R, Klein D, Maggrah A, Klotz L, Parr RL, Dakubo GD. Robinson K, et al. Among authors: parr rl. Prostate Cancer Prostatic Dis. 2010 Jun;13(2):126-31. doi: 10.1038/pcan.2009.64. Epub 2010 Jan 19. Prostate Cancer Prostatic Dis. 2010. PMID: 20084081
Mitochondrial DNA as a potential tool for early cancer detection.
Parr RL, Dakubo GD, Thayer RE, McKenney K, Birch-Machin MA. Parr RL, et al. Hum Genomics. 2006 Jan;2(4):252-7. doi: 10.1186/1479-7364-2-4-252. Hum Genomics. 2006. PMID: 16460650 Free PMC article.
Somatic mitochondrial DNA mutations in prostate cancer and normal appearing adjacent glands in comparison to age-matched prostate samples without malignant histology.
Parr RL, Dakubo GD, Crandall KA, Maki J, Reguly B, Aguirre A, Wittock R, Robinson K, Alexander JS, Birch-Machin MA, Abdel-Malak M, Froberg MK, Diamandis EP, Thayer RE. Parr RL, et al. J Mol Diagn. 2006 Jul;8(3):312-9. doi: 10.2353/jmoldx.2006.050112. J Mol Diagn. 2006. PMID: 16825503 Free PMC article.
The mitochondrial genome: a biosensor for early cancer detection?
Parr RL, Jakupciak JP, Birch-Machin MA, Dakubo GD. Parr RL, et al. Expert Opin Med Diagn. 2007 Oct;1(2):169-82. doi: 10.1517/17530059.1.2.169. Expert Opin Med Diagn. 2007. PMID: 23489304
Altered metabolism and mitochondrial genome in prostate cancer.
Dakubo GD, Parr RL, Costello LC, Franklin RB, Thayer RE. Dakubo GD, et al. J Clin Pathol. 2006 Jan;59(1):10-6. doi: 10.1136/jcp.2005.027664. J Clin Pathol. 2006. PMID: 16394275 Free PMC article. Review.
3.4 kb mitochondrial genome deletion serves as a surrogate predictive biomarker for prostate cancer in histopathologically benign biopsy cores.
Reguly B, Jakupciak JP, Parr RL. Reguly B, et al. Among authors: parr rl. Can Urol Assoc J. 2010 Oct;4(5):E118-22. doi: 10.5489/cuaj.932. Can Urol Assoc J. 2010. PMID: 20944788 Free PMC article.
Mitochondrial genome deletion aids in the identification of false- and true-negative prostate needle core biopsy specimens.
Maki J, Robinson K, Reguly B, Alexander J, Wittock R, Aguirre A, Diamandis EP, Escott N, Skehan A, Prowse O, Thayer RE, Froberg MK, Wilson MJ, Maragh S, Jakupciak JP, Wagner PD, Srivastava S, Dakubo GD, Parr RL. Maki J, et al. Among authors: parr rl. Am J Clin Pathol. 2008 Jan;129(1):57-66. doi: 10.1309/UJJTH4HFEPWAQ78Q. Am J Clin Pathol. 2008. PMID: 18089489
Mitochondrial and nuclear genomics and the emergence of personalized medicine.
Parr RL, Martin LH. Parr RL, et al. Hum Genomics. 2012 Jul 5;6(1):3. doi: 10.1186/1479-7364-6-3. Hum Genomics. 2012. PMID: 23244780 Free PMC article. Review.
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