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Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.
Garcia-Rua V, Feijoo-Bandin S, Garcia-Vence M, Aragon-Herrera A, Bravo SB, Rodriguez-Penas D, Mosquera-Leal A, Lear PV, Parrington J, Alonso J, Rosello-Lleti E, Portoles M, Rivera M, Gonzalez-Juanatey JR, Lago F. Garcia-Rua V, et al. Among authors: parrington j. J Biosci. 2016 Dec;41(4):643-658. doi: 10.1007/s12038-016-9647-4. J Biosci. 2016. PMID: 27966485
Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.
García-Rúa V, Feijóo-Bandín S, Rodríguez-Penas D, Mosquera-Leal A, Abu-Assi E, Beiras A, María Seoane L, Lear P, Parrington J, Portolés M, Roselló-Lletí E, Rivera M, Gualillo O, Parra V, Hill JA, Rothermel B, González-Juanatey JR, Lago F. García-Rúa V, et al. Among authors: parrington j. J Physiol. 2016 Jun 1;594(11):3061-77. doi: 10.1113/JP271332. Epub 2016 Feb 4. J Physiol. 2016. PMID: 26757341 Free PMC article.
Increased expression of fatty-acid and calcium metabolism genes in failing human heart.
García-Rúa V, Otero MF, Lear PV, Rodríguez-Penas D, Feijóo-Bandín S, Noguera-Moreno T, Calaza M, Álvarez-Barredo M, Mosquera-Leal A, Parrington J, Brugada J, Portolés M, Rivera M, González-Juanatey JR, Lago F. García-Rúa V, et al. Among authors: parrington j. PLoS One. 2012;7(6):e37505. doi: 10.1371/journal.pone.0037505. Epub 2012 Jun 6. PLoS One. 2012. PMID: 22701570 Free PMC article.
Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
Lear PV, González-Touceda D, Porteiro Couto B, Viaño P, Guymer V, Remzova E, Tunn R, Chalasani A, García-Caballero T, Hargreaves IP, Tynan PW, Christian HC, Nogueiras R, Parrington J, Diéguez C. Lear PV, et al. Among authors: parrington j. Endocrinology. 2015 Mar;156(3):975-86. doi: 10.1210/en.2014-1766. Epub 2014 Dec 29. Endocrinology. 2015. PMID: 25545384 Free PMC article.
Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination.
Navarro-Serna S, Hachem A, Canha-Gouveia A, Hanbashi A, Garrappa G, Lopes JS, París-Oller E, Sarrías-Gil L, Flores-Flores C, Bassett A, Sánchez R, Bermejo-Álvarez P, Matás C, Romar R, Parrington J, Gadea J. Navarro-Serna S, et al. Among authors: parrington j. CRISPR J. 2021 Feb;4(1):132-146. doi: 10.1089/crispr.2020.0078. CRISPR J. 2021. PMID: 33616447
Calcium signaling via two-pore channels: local or global, that is the question.
Zhu MX, Ma J, Parrington J, Calcraft PJ, Galione A, Evans AM. Zhu MX, et al. Among authors: parrington j. Am J Physiol Cell Physiol. 2010 Mar;298(3):C430-41. doi: 10.1152/ajpcell.00475.2009. Epub 2009 Dec 16. Am J Physiol Cell Physiol. 2010. PMID: 20018950 Free PMC article. Review.
Targeting Two-Pore Channels: Current Progress and Future Challenges.
Jin X, Zhang Y, Alharbi A, Hanbashi A, Alhoshani A, Parrington J. Jin X, et al. Among authors: parrington j. Trends Pharmacol Sci. 2020 Aug;41(8):582-594. doi: 10.1016/j.tips.2020.06.002. Trends Pharmacol Sci. 2020. PMID: 32679067 Free PMC article. Review.
150 results