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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.
Parrini MC, Lei M, Harrison SC, Mayer BJ. Parrini MC, et al. Mol Cell. 2002 Jan;9(1):73-83. doi: 10.1016/s1097-2765(01)00428-2. Mol Cell. 2002. PMID: 11804587
Spatiotemporal regulation of the Pak1 kinase.
Parrini MC, Matsuda M, de Gunzburg J. Parrini MC, et al. Biochem Soc Trans. 2005 Aug;33(Pt 4):646-8. doi: 10.1042/BST0330646. Biochem Soc Trans. 2005. PMID: 16042564 Review.
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.
Parrini MC, Sadou-Dubourgnoux A, Aoki K, Kunida K, Biondini M, Hatzoglou A, Poullet P, Formstecher E, Yeaman C, Matsuda M, Rossé C, Camonis J. Parrini MC, et al. Mol Cell. 2011 Jun 10;42(5):650-61. doi: 10.1016/j.molcel.2011.03.032. Mol Cell. 2011. PMID: 21658605 Free PMC article.
Dissecting activation of the PAK1 kinase at protrusions in living cells.
Parrini MC, Camonis J, Matsuda M, de Gunzburg J. Parrini MC, et al. J Biol Chem. 2009 Sep 4;284(36):24133-43. doi: 10.1074/jbc.M109.015271. Epub 2009 Jul 1. J Biol Chem. 2009. PMID: 19574218 Free PMC article.
Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling.
Remorino A, De Beco S, Cayrac F, Di Federico F, Cornilleau G, Gautreau A, Parrini MC, Masson JB, Dahan M, Coppey M. Remorino A, et al. Among authors: parrini mc. Cell Rep. 2017 Nov 14;21(7):1922-1935. doi: 10.1016/j.celrep.2017.10.069. Cell Rep. 2017. PMID: 29141223
Cell type-specific regulation of RhoA activity during cytokinesis.
Yoshizaki H, Ohba Y, Parrini MC, Dulyaninova NG, Bresnick AR, Mochizuki N, Matsuda M. Yoshizaki H, et al. Among authors: parrini mc. J Biol Chem. 2004 Oct 22;279(43):44756-62. doi: 10.1074/jbc.M402292200. Epub 2004 Aug 12. J Biol Chem. 2004. PMID: 15308673
A Biologist-Friendly Method to Analyze Cross-Correlation Between Protrusion Dynamics and Membrane Recruitment of Actin Regulators.
Paul-Gilloteaux P, Waharte F, Singh MK, Parrini MC. Paul-Gilloteaux P, et al. Among authors: parrini mc. Methods Mol Biol. 2018;1749:279-289. doi: 10.1007/978-1-4939-7701-7_20. Methods Mol Biol. 2018. PMID: 29526004
Untangling the complexity of PAK1 dynamics: The future challenge.
Parrini MC. Parrini MC. Cell Logist. 2012 Apr 1;2(2):78-83. doi: 10.4161/cl.19817. Cell Logist. 2012. PMID: 23125950 Free PMC article.
Cell motility: The necessity of Rac1 GDP/GTP flux.
Parrini MC, Camonis J. Parrini MC, et al. Commun Integr Biol. 2011 Nov 1;4(6):772-4. doi: 10.4161/cib.17772. Commun Integr Biol. 2011. PMID: 22446552 Free PMC article.
Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility.
Biondini M, Sadou-Dubourgnoux A, Paul-Gilloteaux P, Zago G, Arslanhan MD, Waharte F, Formstecher E, Hertzog M, Yu J, Guerois R, Gautreau A, Scita G, Camonis J, Parrini MC. Biondini M, et al. Among authors: parrini mc. J Cell Sci. 2016 Oct 15;129(20):3756-3769. doi: 10.1242/jcs.187336. Epub 2016 Sep 2. J Cell Sci. 2016. PMID: 27591259
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