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Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.
Guzi TJ, Paruch K, Dwyer MP, Labroli M, Shanahan F, Davis N, Taricani L, Wiswell D, Seghezzi W, Penaflor E, Bhagwat B, Wang W, Gu D, Hsieh Y, Lee S, Liu M, Parry D. Guzi TJ, et al. Among authors: parry d. Mol Cancer Ther. 2011 Apr;10(4):591-602. doi: 10.1158/1535-7163.MCT-10-0928. Epub 2011 Feb 14. Mol Cancer Ther. 2011. PMID: 21321066
Intra-S-phase checkpoint activation by direct CDK2 inhibition.
Zhu Y, Alvarez C, Doll R, Kurata H, Schebye XM, Parry D, Lees E. Zhu Y, et al. Among authors: parry d. Mol Cell Biol. 2004 Jul;24(14):6268-77. doi: 10.1128/MCB.24.14.6268-6277.2004. Mol Cell Biol. 2004. PMID: 15226429 Free PMC article.
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