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The promise and peril of transcriptional profiling in biofilm communities.
An D, Parsek MR. An D, et al. Among authors: parsek mr. Curr Opin Microbiol. 2007 Jun;10(3):292-6. doi: 10.1016/j.mib.2007.05.011. Epub 2007 Jun 18. Curr Opin Microbiol. 2007. PMID: 17573234 Review.
Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm.
Alhede M, Kragh KN, Qvortrup K, Allesen-Holm M, van Gennip M, Christensen LD, Jensen PØ, Nielsen AK, Parsek M, Wozniak D, Molin S, Tolker-Nielsen T, Høiby N, Givskov M, Bjarnsholt T. Alhede M, et al. Among authors: parsek m. PLoS One. 2011;6(11):e27943. doi: 10.1371/journal.pone.0027943. Epub 2011 Nov 21. PLoS One. 2011. PMID: 22132176 Free PMC article.
Quorum sensing signals in development of Pseudomonas aeruginosa biofilms.
Parsek MR, Greenberg EP. Parsek MR, et al. Methods Enzymol. 1999;310:43-55. doi: 10.1016/s0076-6879(99)10005-3. Methods Enzymol. 1999. PMID: 10547781 Review. No abstract available.
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms.
Baker P, Hill PJ, Snarr BD, Alnabelseya N, Pestrak MJ, Lee MJ, Jennings LK, Tam J, Melnyk RA, Parsek MR, Sheppard DC, Wozniak DJ, Howell PL. Baker P, et al. Among authors: parsek mr. Sci Adv. 2016 May 20;2(5):e1501632. doi: 10.1126/sciadv.1501632. eCollection 2016 May. Sci Adv. 2016. PMID: 27386527 Free PMC article.
Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix.
Jennings LK, Storek KM, Ledvina HE, Coulon C, Marmont LS, Sadovskaya I, Secor PR, Tseng BS, Scian M, Filloux A, Wozniak DJ, Howell PL, Parsek MR. Jennings LK, et al. Among authors: parsek mr. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11353-8. doi: 10.1073/pnas.1503058112. Epub 2015 Aug 26. Proc Natl Acad Sci U S A. 2015. PMID: 26311845 Free PMC article.
Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post-transcriptionally by RsmA.
Irie Y, Starkey M, Edwards AN, Wozniak DJ, Romeo T, Parsek MR. Irie Y, et al. Among authors: parsek mr. Mol Microbiol. 2010 Oct;78(1):158-72. doi: 10.1111/j.1365-2958.2010.07320.x. Epub 2010 Aug 2. Mol Microbiol. 2010. PMID: 20735777 Free PMC article.
Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production.
Byrd MS, Sadovskaya I, Vinogradov E, Lu H, Sprinkle AB, Richardson SH, Ma L, Ralston B, Parsek MR, Anderson EM, Lam JS, Wozniak DJ. Byrd MS, et al. Among authors: parsek mr. Mol Microbiol. 2009 Aug;73(4):622-38. doi: 10.1111/j.1365-2958.2009.06795.x. Epub 2009 Jul 29. Mol Microbiol. 2009. PMID: 19659934 Free PMC article.
Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix.
Borlee BR, Goldman AD, Murakami K, Samudrala R, Wozniak DJ, Parsek MR. Borlee BR, et al. Among authors: parsek mr. Mol Microbiol. 2010 Feb;75(4):827-42. doi: 10.1111/j.1365-2958.2009.06991.x. Epub 2010 Jan 17. Mol Microbiol. 2010. PMID: 20088866 Free PMC article.
The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP.
Baraquet C, Murakami K, Parsek MR, Harwood CS. Baraquet C, et al. Among authors: parsek mr. Nucleic Acids Res. 2012 Aug;40(15):7207-18. doi: 10.1093/nar/gks384. Epub 2012 May 11. Nucleic Acids Res. 2012. PMID: 22581773 Free PMC article.
A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack.
Tseng BS, Reichhardt C, Merrihew GE, Araujo-Hernandez SA, Harrison JJ, MacCoss MJ, Parsek MR. Tseng BS, et al. Among authors: parsek mr. mBio. 2018 Apr 10;9(2):e00543-18. doi: 10.1128/mBio.00543-18. mBio. 2018. PMID: 29636440 Free PMC article.
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