Parsonage D - Search Results

1

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.

Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. Debnath A, et al. Among authors: parsonage d. Nat Med. 2012 Jun;18(6):956-60. doi: 10.1038/nm.2758. Nat Med. 2012. PMID: 22610278 Free PMC article.

2

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.

Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. Parsonage D, et al. J Struct Biol. 2016 May;194(2):180-90. doi: 10.1016/j.jsb.2016.02.015. Epub 2016 Feb 12. J Struct Biol. 2016. PMID: 26876147 Free PMC article.

3

Engineering of fluorescent reporters into redox domains to monitor electron transfers.

Parsonage D, Reeves SA, Karplus PA, Poole LB. Parsonage D, et al. Methods Enzymol. 2010;474:1-21. doi: 10.1016/S0076-6879(10)74001-5. Epub 2010 Jun 20. Methods Enzymol. 2010. PMID: 20609901

4

Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin.

Parsonage D, Karplus PA, Poole LB. Parsonage D, et al. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8209-14. doi: 10.1073/pnas.0708308105. Epub 2007 Dec 28. Proc Natl Acad Sci U S A. 2008. PMID: 18165315 Free PMC article.

5

Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.

Nelson KJ, Parsonage D, Karplus PA, Poole LB. Nelson KJ, et al. Among authors: parsonage d. Methods Enzymol. 2013;527:21-40. doi: 10.1016/B978-0-12-405882-8.00002-7. Methods Enzymol. 2013. PMID: 23830624 Free PMC article.

6

Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.

Reeves SA, Parsonage D, Nelson KJ, Poole LB. Reeves SA, et al. Among authors: parsonage d. Biochemistry. 2011 Oct 18;50(41):8970-81. doi: 10.1021/bi200935d. Epub 2011 Sep 21. Biochemistry. 2011. PMID: 21910476 Free PMC article.

7

Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization.

Hall A, Parsonage D, Poole LB, Karplus PA. Hall A, et al. Among authors: parsonage d. J Mol Biol. 2010 Sep 10;402(1):194-209. doi: 10.1016/j.jmb.2010.07.022. Epub 2010 Jul 17. J Mol Biol. 2010. PMID: 20643143 Free PMC article.

8

Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.

Buchko GW, Perkins A, Parsonage D, Poole LB, Karplus PA. Buchko GW, et al. Among authors: parsonage d. Biomol NMR Assign. 2016 Apr;10(1):57-61. doi: 10.1007/s12104-015-9637-8. Epub 2015 Sep 15. Biomol NMR Assign. 2016. PMID: 26438558 Free PMC article.

9

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.

Perkins A, Nelson KJ, Parsonage D, Poole LB, Karplus PA. Perkins A, et al. Among authors: parsonage d. Trends Biochem Sci. 2015 Aug;40(8):435-45. doi: 10.1016/j.tibs.2015.05.001. Epub 2015 Jun 9. Trends Biochem Sci. 2015. PMID: 26067716 Free PMC article. Review.

10

Cysteine pK(a) values for the bacterial peroxiredoxin AhpC.

Nelson KJ, Parsonage D, Hall A, Karplus PA, Poole LB. Nelson KJ, et al. Among authors: parsonage d. Biochemistry. 2008 Dec 2;47(48):12860-8. doi: 10.1021/bi801718d. Biochemistry. 2008. PMID: 18986167 Free PMC article.

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