Pascal JM - Search Results

1

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.

Riccio AA, Cingolani G, Pascal JM. Riccio AA, et al. Among authors: pascal jm. Nucleic Acids Res. 2016 Feb 29;44(4):1691-702. doi: 10.1093/nar/gkv1376. Epub 2015 Dec 23. Nucleic Acids Res. 2016. PMID: 26704974 Free PMC article.

2

A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation.

Langelier MF, Servent KM, Rogers EE, Pascal JM. Langelier MF, et al. Among authors: pascal jm. J Biol Chem. 2008 Feb 15;283(7):4105-14. doi: 10.1074/jbc.M708558200. Epub 2007 Nov 30. J Biol Chem. 2008. PMID: 18055453 Free article.

3

The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.

Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM. Langelier MF, et al. Among authors: pascal jm. J Biol Chem. 2010 Jun 11;285(24):18877-87. doi: 10.1074/jbc.M110.105668. Epub 2010 Apr 13. J Biol Chem. 2010. PMID: 20388712 Free PMC article.

4

Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.

Langelier MF, Planck JL, Roy S, Pascal JM. Langelier MF, et al. Among authors: pascal jm. J Biol Chem. 2011 Mar 25;286(12):10690-701. doi: 10.1074/jbc.M110.202507. Epub 2011 Jan 13. J Biol Chem. 2011. PMID: 21233213 Free PMC article.

5

Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis.

Langelier MF, Planck JL, Servent KM, Pascal JM. Langelier MF, et al. Among authors: pascal jm. Methods Mol Biol. 2011;780:209-26. doi: 10.1007/978-1-61779-270-0_13. Methods Mol Biol. 2011. PMID: 21870263

6

Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.

Langelier MF, Planck JL, Roy S, Pascal JM. Langelier MF, et al. Among authors: pascal jm. Science. 2012 May 11;336(6082):728-32. doi: 10.1126/science.1216338. Science. 2012. PMID: 22582261 Free PMC article.

7

Dual roles of PARP-1 promote cancer growth and progression.

Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, Pascal JM, Centenera MM, Butler LM, Tilley WD, Feng FY, Knudsen KE. Schiewer MJ, et al. Among authors: pascal jm. Cancer Discov. 2012 Dec;2(12):1134-49. doi: 10.1158/2159-8290.CD-12-0120. Epub 2012 Sep 19. Cancer Discov. 2012. PMID: 22993403 Free PMC article.

8

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.

Langelier MF, Pascal JM. Langelier MF, et al. Among authors: pascal jm. Curr Opin Struct Biol. 2013 Feb;23(1):134-43. doi: 10.1016/j.sbi.2013.01.003. Epub 2013 Jan 16. Curr Opin Struct Biol. 2013. PMID: 23333033 Free PMC article. Review.

9

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Steffen JD, Tholey RM, Langelier MF, Planck JL, Schiewer MJ, Lal S, Bildzukewicz NA, Yeo CJ, Knudsen KE, Brody JR, Pascal JM. Steffen JD, et al. Among authors: pascal jm. Cancer Res. 2014 Jan 1;74(1):31-7. doi: 10.1158/0008-5472.CAN-13-1701. Epub 2013 Nov 4. Cancer Res. 2014. PMID: 24189460 Free PMC article.

10

PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.

Langelier MF, Riccio AA, Pascal JM. Langelier MF, et al. Among authors: pascal jm. Nucleic Acids Res. 2014 Jul;42(12):7762-75. doi: 10.1093/nar/gku474. Epub 2014 Jun 13. Nucleic Acids Res. 2014. PMID: 24928857 Free PMC article.

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