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Expression of stress ligands of the immunoreceptor NKG2D in melanoma: regulation and clinical significance.
Paschen A, Baingo J, Schadendorf D. Paschen A, et al. Eur J Cell Biol. 2014 Jan-Feb;93(1-2):49-54. doi: 10.1016/j.ejcb.2014.01.009. Epub 2014 Feb 11. Eur J Cell Biol. 2014. PMID: 24629838 Review.
Here we review important aspects of NKG2DL expression and regulation in tumor cells with a focus on melanoma, and discuss their clinical relevance and potential in immunotherapy....
Here we review important aspects of NKG2DL expression and regulation in tumor cells with a focus on melanoma, and discuss their clini …
Complete loss of HLA class I antigen expression on melanoma cells: a result of successive mutational events.
Paschen A, Méndez RM, Jimenez P, Sucker A, Ruiz-Cabello F, Song M, Garrido F, Schadendorf D. Paschen A, et al. Int J Cancer. 2003 Mar 1;103(6):759-67. doi: 10.1002/ijc.10906. Int J Cancer. 2003. PMID: 12516095
We detected complete loss of HLA class I antigen presentation for 2 tumor cell lines from 1 melanoma patient, the first originated from a regional lymph node lesion diagnosed simultaneously with the primary tumor and the second established 8 months later from a meta …
We detected complete loss of HLA class I antigen presentation for 2 tumor cell lines from 1 melanoma patient, the first originated from a
Evaluation of combined gene regulatory elements for transcriptional targeting of suicide gene expression to malignant melanoma.
Rothfels H, Paschen A, Schadendorf D. Rothfels H, et al. Exp Dermatol. 2003 Dec;12(6):799-810. doi: 10.1111/j.0906-6705.2003.00093.x. Exp Dermatol. 2003. PMID: 14714561
Two tissue-specific (tyrosine and MIA) promoters and one weak viral promoter were fused to multiple tandem copies of a melanocyte-specific enhancer element. ...In contrast, when those combinations were employed to drive the expression of two suicide genes, encoding the dip …
Two tissue-specific (tyrosine and MIA) promoters and one weak viral promoter were fused to multiple tandem copies of a melanocyte-spe …
Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.
Paschen A, Jing W, Drexler I, Klemm M, Song M, Müller-Berghaus J, Nguyen XD, Osen W, Stevanovic S, Sutter G, Schadendorf D. Paschen A, et al. Int J Cancer. 2005 Oct 10;116(6):944-8. doi: 10.1002/ijc.21132. Int J Cancer. 2005. PMID: 15856458
This led to the identification of TRP-2(181-190) as the first HLA-A*01-presented TRP-2-derived epitope. T-cell lines specific for peptide TRP-2(181-190) could be established from PBL of 50% of the normal HLA-A*01(+) donors tested. ...Because TRP-2(181-190) overlaps …
This led to the identification of TRP-2(181-190) as the first HLA-A*01-presented TRP-2-derived epitope. T-cell lines specific for pep …
Detection of spontaneous CD4+ T-cell responses in melanoma patients against a tyrosinase-related protein-2-derived epitope identified in HLA-DRB1*0301 transgenic mice.
Paschen A, Song M, Osen W, Nguyen XD, Mueller-Berghaus J, Fink D, Daniel N, Donzeau M, Nagel W, Kropshofer H, Schadendorf D. Paschen A, et al. Clin Cancer Res. 2005 Jul 15;11(14):5241-7. doi: 10.1158/1078-0432.CCR-05-0170. Clin Cancer Res. 2005. PMID: 16033842
As a prerequisite for immunization, T-cell epitopes have to be identified. Whereas a number of HLA class I-presented TRP-2-derived epitopes are known, information about HLA class II-presented antigenic ligands recognized by CD4+ T helper (Th) cells is limited. ...CO …
As a prerequisite for immunization, T-cell epitopes have to be identified. Whereas a number of HLA class I-presented TRP-2-der …
The coincidence of chromosome 15 aberrations and beta2-microglobulin gene mutations is causative for the total loss of human leukocyte antigen class I expression in melanoma.
Paschen A, Arens N, Sucker A, Greulich-Bode KM, Fonsatti E, Gloghini A, Striegel S, Schwinn N, Carbone A, Hildenbrand R, Cerwenka A, Maio M, Schadendorf D. Paschen A, et al. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3297-305. doi: 10.1158/1078-0432.CCR-05-2174. Clin Cancer Res. 2006. PMID: 16740750
Two of the four cell lines exhibited a special type of intrachromosomal rearrangement characterized by FISH signals specific for the subtelomeric region of 15q at both ends of the chromosome and one centromeric signal in between. CONCLUSIONS: Our data indicate that the com …
Two of the four cell lines exhibited a special type of intrachromosomal rearrangement characterized by FISH signals specific for the …
Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells.
Schwinn N, Vokhminova D, Sucker A, Textor S, Striegel S, Moll I, Nausch N, Tuettenberg J, Steinle A, Cerwenka A, Schadendorf D, Paschen A. Schwinn N, et al. Int J Cancer. 2009 Apr 1;124(7):1594-604. doi: 10.1002/ijc.24098. Int J Cancer. 2009. PMID: 19089914
Ligands of NKG2D, the MHC class I chain-related (MIC) and UL16 binding protein (ULBP) molecules, are expressed on a variety of human tumors, including melanoma. ...Instead, quantitative RT-PCR revealed a decrease of MICA-specific mRNA levels upon IFN-gamma treatment …
Ligands of NKG2D, the MHC class I chain-related (MIC) and UL16 binding protein (ULBP) molecules, are expressed on a variety of human …
Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase.
Jarahian M, Watzl C, Fournier P, Arnold A, Djandji D, Zahedi S, Cerwenka A, Paschen A, Schirrmacher V, Momburg F. Jarahian M, et al. J Virol. 2009 Aug;83(16):8108-21. doi: 10.1128/JVI.00211-09. Epub 2009 Jun 10. J Virol. 2009. PMID: 19515783 Free PMC article.
Hemagglutinin-neuraminidase (HN) of the virus serves as a ligand structure for NKp44 and NKp46, as indicated by the blockade of binding to NDV-infected cells and viral particles in the presence of anti-HN antibodies and by binding to cells transfected with HN cDNA. ...
Hemagglutinin-neuraminidase (HN) of the virus serves as a ligand structure for NKp44 and NKp46, as indicated by the blockade of bindi …
Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B.
Paschen A, Sucker A, Hill B, Moll I, Zapatka M, Nguyen XD, Sim GC, Gutmann I, Hassel J, Becker JC, Steinle A, Schadendorf D, Ugurel S. Paschen A, et al. Clin Cancer Res. 2009 Aug 15;15(16):5208-15. doi: 10.1158/1078-0432.CCR-09-0886. Epub 2009 Aug 11. Clin Cancer Res. 2009. PMID: 19671853
PURPOSE: Cytotoxic lymphocytes interact with human tumor cells via the activating immunoreceptor NKG2D, recognizing a variety of stress-associated MIC and ULBP surface molecules. ...RESULTS: Immunohistochemistry revealed a heterogeneous expression of MIC and ULBP2 m …
PURPOSE: Cytotoxic lymphocytes interact with human tumor cells via the activating immunoreceptor NKG2D, recognizing a variety of stre …
Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.
Heinemann A, Zhao F, Pechlivanis S, Eberle J, Steinle A, Diederichs S, Schadendorf D, Paschen A. Heinemann A, et al. Cancer Res. 2012 Jan 15;72(2):460-71. doi: 10.1158/0008-5472.CAN-11-1977. Epub 2011 Nov 18. Cancer Res. 2012. PMID: 22102694
Treatment with the small molecule inhibitor Nutlin-3a also decreased ULBP2 levels in a p53-dependent manner, which was due to a p53-mediated increase in cellular miR-34 levels. ...
Treatment with the small molecule inhibitor Nutlin-3a also decreased ULBP2 levels in a p53-dependent manner, which was due to a
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