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Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.
Moreau A, Vilarem MJ, Maurel P, Pascussi JM. Moreau A, et al. Among authors: pascussi jm. Mol Pharm. 2008 Jan-Feb;5(1):35-41. doi: 10.1021/mp700103m. Epub 2007 Dec 27. Mol Pharm. 2008. PMID: 18159929 Review.
Characterization of a novel PXR isoform with potential dominant-negative properties.
Breuker C, Planque C, Rajabi F, Nault JC, Couchy G, Zucman-Rossi J, Evrard A, Kantar J, Chevet E, Bioulac-Sage P, Ramos J, Assenat E, Joubert D, Pannequin J, Hollande F, Pascussi JM. Breuker C, et al. Among authors: pascussi jm. J Hepatol. 2014 Sep;61(3):609-16. doi: 10.1016/j.jhep.2014.04.030. Epub 2014 May 2. J Hepatol. 2014. PMID: 24798619
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L. Marmugi A, et al. Among authors: pascussi jm. Toxicol Appl Pharmacol. 2016 Jul 15;303:90-100. doi: 10.1016/j.taap.2016.05.006. Epub 2016 May 11. Toxicol Appl Pharmacol. 2016. PMID: 27180240
The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.
Ayed-Boussema I, Pascussi JM, Rjiba K, Maurel P, Bacha H, Hassen W. Ayed-Boussema I, et al. Among authors: pascussi jm. Drug Chem Toxicol. 2012 Jul;35(3):241-50. doi: 10.3109/01480545.2011.592194. Epub 2011 Sep 22. Drug Chem Toxicol. 2012. PMID: 21939362
Different activation patterns of rat xenobiotic metabolism genes by two constituents of garlic.
Zhang P, Noordine ML, Cherbuy C, Vaugelade P, Pascussi JM, Duée PH, Thomas M. Zhang P, et al. Among authors: pascussi jm. Carcinogenesis. 2006 Oct;27(10):2090-5. doi: 10.1093/carcin/bgl064. Epub 2006 May 5. Carcinogenesis. 2006. PMID: 16679304
Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms.
Pascussi JM, Robert A, Moreau A, Ramos J, Bioulac-Sage P, Navarro F, Blanc P, Assenat E, Maurel P, Vilarem MJ. Pascussi JM, et al. Hepatology. 2007 May;45(5):1146-53. doi: 10.1002/hep.21592. Hepatology. 2007. PMID: 17464991
Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.
Pascussi JM, Robert A, Nguyen M, Walrant-Debray O, Garabedian M, Martin P, Pineau T, Saric J, Navarro F, Maurel P, Vilarem MJ. Pascussi JM, et al. J Clin Invest. 2005 Jan;115(1):177-86. doi: 10.1172/JCI21867. J Clin Invest. 2005. PMID: 15630458 Free PMC article.
Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.
Assenat E, Gerbal-Chaloin S, Larrey D, Saric J, Fabre JM, Maurel P, Vilarem MJ, Pascussi JM. Assenat E, et al. Among authors: pascussi jm. Hepatology. 2004 Oct;40(4):951-60. doi: 10.1002/hep.20387. Hepatology. 2004. PMID: 15382119
Pathophysiological factors affecting CAR gene expression.
Pascussi JM, Dvorák Z, Gerbal-Chaloin S, Assenat E, Maurel P, Vilarem MJ. Pascussi JM, et al. Drug Metab Rev. 2003 Nov;35(4):255-68. doi: 10.1081/dmr-120026394. Drug Metab Rev. 2003. PMID: 14705859 Review.
Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element.
Pascussi JM, Busson-Le Coniat M, Maurel P, Vilarem MJ. Pascussi JM, et al. Mol Endocrinol. 2003 Jan;17(1):42-55. doi: 10.1210/me.2002-0244. Mol Endocrinol. 2003. PMID: 12511605
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