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Pasireotide, an IGF-I action inhibitor, prevents growth hormone and estradiol-induced mammary hyperplasia.
Kleinberg DL, Ameri P, Singh B. Kleinberg DL, et al. Pituitary. 2011 Mar;14(1):44-52. doi: 10.1007/s11102-010-0257-0. Pituitary. 2011. PMID: 20890664
After 7 days all terminal end buds (TEBs) and 75% of ducts became hyperplastic. Co-treatment with pasireotide, a somatostatin analog that blocks GH secretion and IGF-I action in the mammary gland, prevented hormone-induced hyperplasia. ...As tamoxifen did not …
After 7 days all terminal end buds (TEBs) and 75% of ducts became hyperplastic. Co-treatment with pasireotide, a somatostatin analog …
Insulin-like growth factor-I inhibition with pasireotide decreases cell proliferation and increases apoptosis in pre-malignant lesions of the breast: a phase 1 proof of principle trial.
Singh B, Smith JA, Axelrod DM, Ameri P, Levitt H, Danoff A, Lesser M, de Angelis C, Illa-Bochaca I, Lubitz S, Huberman D, Darvishian F, Kleinberg DL. Singh B, et al. Breast Cancer Res. 2014 Nov 11;16(6):463. doi: 10.1186/s13058-014-0463-1. Breast Cancer Res. 2014. PMID: 25385439 Free PMC article. Clinical Trial.
As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and has other direct effects on mammary development and carcinogenesis, we hypothesized that IGF-I inhibition might provide a novel approach f …
As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and has o …
Prevention of breast cancer: the case for studying inhibition of IGF-1 actions.
Smith J, Axelrod D, Singh B, Kleinberg D. Smith J, et al. Ann Oncol. 2011 Jan;22 Suppl 1:i50-2. doi: 10.1093/annonc/mdq666. Ann Oncol. 2011. PMID: 21285152 Free article.
Based on the importance of the insulin-like growth factor-1 pathway in mammary gland development, and the availability of a potent inhibitor, pilot studies are ongoing to evaluate such an inhibitor in women with demonstrable high risk to develop breast …
Based on the importance of the insulin-like growth factor-1 pathway in mammary gland development, and the availability of a po …