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Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.
Husain SR, Behari N, Kreitman RJ, Pastan I, Puri RK. Husain SR, et al. Cancer Res. 1998 Aug 15;58(16):3649-53. Cancer Res. 1998. PMID: 9721874
A significant antitumor activity was also observed when the IL-4 toxin was administered via i.p. and i.v. routes. These results demonstrate that the IL-4 toxin may be a new therapeutic drug for the treatment of human glioblastoma. Therefore, we have begun a Phase …
A significant antitumor activity was also observed when the IL-4 toxin was administered via i.p. and i.v. routes. These result …
Targeting growth factor receptors with fusion toxins.
Kreitman RJ, FitzGerald D, Pastan I. Kreitman RJ, et al. Int J Immunopharmacol. 1992 Apr;14(3):465-72. doi: 10.1016/0192-0561(92)90177-m. Int J Immunopharmacol. 1992. PMID: 1319965 Review.
Frequent expression of the tumor antigen CAK1 in squamous-cell carcinomas.
Chang K, Pastan I, Willingham MC. Chang K, et al. Int J Cancer. 1992 Jun 19;51(4):548-54. doi: 10.1002/ijc.2910510408. Int J Cancer. 1992. PMID: 1351045
Two patterns of CAK1 expression in tumor samples were found, i.e., a heterogeneous pattern with strong intensity, and a homogeneous pattern with weak intensity. ...
Two patterns of CAK1 expression in tumor samples were found, i.e., a heterogeneous pattern with strong intensity, and a homogeneous p …
Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin.
Batra JK, Kasprzyk PG, Bird RE, Pastan I, King CR. Batra JK, et al. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5867-71. doi: 10.1073/pnas.89.13.5867. Proc Natl Acad Sci U S A. 1992. PMID: 1352878 Free PMC article.
Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.
Merwin JR, Lynch MJ, Madri JA, Pastan I, Siegall CB. Merwin JR, et al. Cancer Res. 1992 Sep 15;52(18):4995-5001. Cancer Res. 1992. PMID: 1381275
RFCs were also cultured in a 3-dimensional type I collagen gel and incubated with either transforming growth factor beta 1, aFGF-PE, or a combination of both. ...
RFCs were also cultured in a 3-dimensional type I collagen gel and incubated with either transforming growth factor beta 1, aFGF-PE, …
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