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Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers.
Pastor F, Kolonias D, McNamara JO 2nd, Gilboa E. Pastor F, et al. Mol Ther. 2011 Oct;19(10):1878-86. doi: 10.1038/mt.2011.145. Epub 2011 Aug 9. Mol Ther. 2011. PMID: 21829171 Free PMC article.
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
McNamara JO, Kolonias D, Pastor F, Mittler RS, Chen L, Giangrande PH, Sullenger B, Gilboa E. McNamara JO, et al. Among authors: pastor f. J Clin Invest. 2008 Jan;118(1):376-86. doi: 10.1172/JCI33365. J Clin Invest. 2008. PMID: 18060045 Free PMC article.
Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay.
Pastor F, Kolonias D, Giangrande PH, Gilboa E. Pastor F, et al. Nature. 2010 May 13;465(7295):227-30. doi: 10.1038/nature08999. Nature. 2010. PMID: 20463739 Free PMC article.
Use of oligonucleotide aptamer ligands to modulate the function of immune receptors.
Gilboa E, McNamara J 2nd, Pastor F. Gilboa E, et al. Among authors: pastor f. Clin Cancer Res. 2013 Mar 1;19(5):1054-62. doi: 10.1158/1078-0432.CCR-12-2067. Clin Cancer Res. 2013. PMID: 23460536
CD28 aptamers as powerful immune response modulators.
Pastor F, Soldevilla MM, Villanueva H, Kolonias D, Inoges S, de Cerio AL, Kandzia R, Klimyuk V, Gleba Y, Gilboa E, Bendandi M. Pastor F, et al. Mol Ther Nucleic Acids. 2013 Jun 11;2(6):e98. doi: 10.1038/mtna.2013.26. Mol Ther Nucleic Acids. 2013. PMID: 23756353 Free PMC article.
2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia.
Soldevilla MM, Villanueva H, Bendandi M, Inoges S, López-Díaz de Cerio A, Pastor F. Soldevilla MM, et al. Among authors: pastor f. Biomaterials. 2015 Oct;67:274-85. doi: 10.1016/j.biomaterials.2015.07.020. Epub 2015 Jul 14. Biomaterials. 2015. PMID: 26231918
MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells.
Soldevilla MM, Villanueva H, Casares N, Lasarte JJ, Bendandi M, Inoges S, López-Díaz de Cerio A, Pastor F. Soldevilla MM, et al. Among authors: pastor f. Oncotarget. 2016 Apr 26;7(17):23182-96. doi: 10.18632/oncotarget.8095. Oncotarget. 2016. PMID: 26992239 Free PMC article.
Targeting inhibition of Foxp3 by a CD28 2'-Fluro oligonucleotide aptamer conjugated to P60-peptide enhances active cancer immunotherapy.
Lozano T, Soldevilla MM, Casares N, Villanueva H, Bendandi M, Lasarte JJ, Pastor F. Lozano T, et al. Among authors: pastor f. Biomaterials. 2016 Jun;91:73-80. doi: 10.1016/j.biomaterials.2016.03.007. Epub 2016 Mar 8. Biomaterials. 2016. PMID: 26999456
Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA).
Soldevilla MM, Hervas S, Villanueva H, Lozano T, Rabal O, Oyarzabal J, Lasarte JJ, Bendandi M, Inoges S, López-Díaz de Cerio A, Pastor F. Soldevilla MM, et al. Among authors: pastor f. PLoS One. 2017 Sep 21;12(9):e0185169. doi: 10.1371/journal.pone.0185169. eCollection 2017. PLoS One. 2017. PMID: 28934318 Free PMC article.
ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity.
Soldevilla MM, Villanueva H, Meraviglia-Crivelli D, Menon AP, Ruiz M, Cebollero J, Villalba M, Moreno B, Lozano T, Llopiz D, Pejenaute Á, Sarobe P, Pastor F. Soldevilla MM, et al. Among authors: pastor f. Mol Ther. 2019 Nov 6;27(11):1878-1891. doi: 10.1016/j.ymthe.2019.07.013. Epub 2019 Jul 25. Mol Ther. 2019. PMID: 31405808 Free PMC article.
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