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Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.
Patel A; ADVANCE Collaborative Group, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B. Patel A, et al. Lancet. 2007 Sep 8;370(9590):829-40. doi: 10.1016/S0140-6736(07)61303-8. Lancet. 2007. PMID: 17765963 Clinical Trial.
After a 6-week active run-in period, 11 140 patients with type 2 diabetes were randomised to treatment with a fixed combination of perindopril and indapamide or matching placebo, in addition to current therapy. ...FINDINGS: After a mean of 4.3 years of follow …
After a 6-week active run-in period, 11 140 patients with type 2 diabetes were randomised to treatment with a fixed combinatio …
Diabetes and vascular disease: a new international trial.
Patel A, Chalmers J, Chaturvedi V, Currie R, Monaghan H, Neal B. Patel A, et al. Asian Cardiovasc Thorac Ann. 2003 Jun;11(2):180-4. doi: 10.1177/021849230301100224. Asian Cardiovasc Thorac Ann. 2003. PMID: 12878575 Review.
We discuss the scope and implications of the increasing burden of diabetes and describe the rationale and design of a new international study examining blood pressure lowering and glucose control interventions aimed at reducing the risk of vascular complications in people …
We discuss the scope and implications of the increasing burden of diabetes and describe the rationale and design of a new internation …
Prediction of heart failure by amino terminal-pro-B-type natriuretic peptide and C-reactive protein in subjects with cerebrovascular disease.
Campbell DJ, Woodward M, Chalmers JP, Colman SA, Jenkins AJ, Kemp BE, Neal BC, Patel A, MacMahon SW. Campbell DJ, et al. Hypertension. 2005 Jan;45(1):69-74. doi: 10.1161/01.HYP.0000151103.02424.c3. Epub 2004 Nov 29. Hypertension. 2005. PMID: 15569851
To evaluate amino terminal-pro-BNP (NT-proBNP) and CRP, separately and together, for assessment of risk of CHF, we performed a nested case-control study of the 6105 participants of the Perindopril pROtection aGainst REcurrent Stroke Study (PROGRESS), a placebo-contr …
To evaluate amino terminal-pro-BNP (NT-proBNP) and CRP, separately and together, for assessment of risk of CHF, we performed a nested …
Plasma lipids predict myocardial infarction, but not stroke, in patients with established cerebrovascular disease.
Patel A, Woodward M, Campbell DJ, Sullivan DR, Colman S, Chalmers J, Neal B, MacMahon S. Patel A, et al. Eur Heart J. 2005 Sep;26(18):1910-5. doi: 10.1093/eurheartj/ehi407. Epub 2005 Jul 8. Eur Heart J. 2005. PMID: 16006443 Clinical Trial.
A series of nested case-control studies were used to investigate the association between each of these lipid variables and the risk of subsequent haemorrhagic stroke, ischaemic stroke, myocardial infarction (MI), and heart failure. A total of 895 patients were selec
A series of nested case-control studies were used to investigate the association between each of these lipid variables and the risk o
Associations of inflammatory and hemostatic variables with the risk of recurrent stroke.
Woodward M, Lowe GD, Campbell DJ, Colman S, Rumley A, Chalmers J, Neal BC, Patel A, Jenkins AJ, Kemp BE, MacMahon SW. Woodward M, et al. Stroke. 2005 Oct;36(10):2143-7. doi: 10.1161/01.STR.0000181754.38408.4c. Epub 2005 Sep 8. Stroke. 2005. PMID: 16151030 Clinical Trial.
We studied such associations in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS). METHODS: Nested case-control study of ischemic (n=472) and hemorrhagic (n=83) strokes occurring during a randomized, placeb …
We studied such associations in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (P …
Does sex matter in the associations between classic risk factors and fatal coronary heart disease in populations from the Asia-Pacific region?
Huxley R, Woodward M, Barzi F, Wong JW, Pan WH, Patel A; Asia Pacific Cohort Studies Collaboration. Huxley R, et al. J Womens Health (Larchmt). 2005 Nov;14(9):820-8. doi: 10.1089/jwh.2005.14.820. J Womens Health (Larchmt). 2005. PMID: 16313209
A significant sex interaction was observed between systolic blood pressure (SBP) and CHD mortality such that a 10 mm Hg increase was associated with a 15% greater increase in the relative risk (RR) of coronary death in women compared with men (p = 0.002). CON
A significant sex interaction was observed between systolic blood pressure (SBP) and CHD mortality such that a 10 mm Hg increa
Serum lipid levels and the prevalence of dyslipidaemia among rural and urban Thai adults--are the NCEP III guidelines appropriate?
Patel A, Woodward M, Stolk R, Suriyawongpaisal P, Neal B. Patel A, et al. J Med Assoc Thai. 2005 Sep;88(9):1242-50. J Med Assoc Thai. 2005. PMID: 16536111
Fasting serum lipids were measured in a population-based survey that included 5305 rural and urban Thai adults aged 335 years. ...
Fasting serum lipids were measured in a population-based survey that included 5305 rural and urban Thai adults aged 335 years. ...
A randomised trial of the effects of an additional communication strategy on recruitment into a large-scale, multi-centre trial.
Monaghan H, Richens A, Colman S, Currie R, Girgis S, Jayne K, Neal B, Patel A. Monaghan H, et al. Contemp Clin Trials. 2007 Jan;28(1):1-5. doi: 10.1016/j.cct.2006.06.004. Epub 2006 Aug 14. Contemp Clin Trials. 2007. PMID: 16904951 Clinical Trial.
Timely participant recruitment remains a significant challenge for most clinical trials. We evaluated the effects on participant recruitment of communication between the central trial coordinators and the clinical sites in the setting of a large international multi- …
Timely participant recruitment remains a significant challenge for most clinical trials. We evaluated the effects on participant recr …
ADVANCE: breaking new ground in type 2 diabetes.
Chalmers J, Perkovic V, Joshi R, Patel A. Chalmers J, et al. J Hypertens Suppl. 2006 Aug;24(5):S22-8. doi: 10.1097/01.hjh.0000240043.50838.28. J Hypertens Suppl. 2006. PMID: 16936533 Clinical Trial.
OBJECTIVE AND RATIONALE: ADVANCE (Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation) is a large-scale trial designed to investigate the benefits of blood pressure lowering and intensive glucose control in patients with type 2 diabetes …
OBJECTIVE AND RATIONALE: ADVANCE (Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation) is a larg …
How important is diabetes as a risk factor for cardiovascular and other diseases in older adults?
Kengne AP, Patel A. Kengne AP, et al. PLoS Med. 2006 Oct;3(10):e424. doi: 10.1371/journal.pmed.0030424. PLoS Med. 2006. PMID: 17048981 Free PMC article. Review.
Patel and Kengne discuss a new study inPLoS Medicine which found a 2-fold increased risk of cardiovascular death associated with diabetes in people over 65 years old....
Patel and Kengne discuss a new study inPLoS Medicine which found a 2-fold increased risk of cardiovascular death associ
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