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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.
Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Rothhammer V, et al. Among authors: patel b. Nat Med. 2016 Jun;22(6):586-97. doi: 10.1038/nm.4106. Epub 2016 May 9. Nat Med. 2016. PMID: 27158906 Free PMC article.
IL-21 induces IL-22 production in CD4+ T cells.
Yeste A, Mascanfroni ID, Nadeau M, Burns EJ, Tukpah AM, Santiago A, Wu C, Patel B, Kumar D, Quintana FJ. Yeste A, et al. Among authors: patel b. Nat Commun. 2014 May 6;5:3753. doi: 10.1038/ncomms4753. Nat Commun. 2014. PMID: 24796415 Free PMC article.
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Mayo L, et al. Among authors: patel b. Nat Med. 2014 Oct;20(10):1147-56. doi: 10.1038/nm.3681. Epub 2014 Sep 14. Nat Med. 2014. PMID: 25216636 Free PMC article.
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Mascanfroni ID, et al. Among authors: patel b. Nat Med. 2015 Jun;21(6):638-46. doi: 10.1038/nm.3868. Epub 2015 May 25. Nat Med. 2015. PMID: 26005855 Free PMC article.
Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.
Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. Yeste A, et al. Among authors: patel b. Sci Signal. 2016 Jun 21;9(433):ra61. doi: 10.1126/scisignal.aad0612. Sci Signal. 2016. PMID: 27330188 Free article.
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. Goettel JA, et al. Among authors: patel b. Cell Rep. 2016 Oct 25;17(5):1318-1329. doi: 10.1016/j.celrep.2016.09.082. Cell Rep. 2016. PMID: 27783946 Free PMC article.
Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.
Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Farez MF, et al. Among authors: patel b. Cell. 2015 Sep 10;162(6):1338-52. doi: 10.1016/j.cell.2015.08.025. Cell. 2015. PMID: 26359987 Free PMC article.
Alterations of the human gut microbiome in multiple sclerosis.
Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL. Jangi S, et al. Among authors: patel b. Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015. Nat Commun. 2016. PMID: 27352007 Free PMC article.
Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.
Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL. Hu D, et al. Among authors: patel b. Nat Commun. 2017 Nov 17;8(1):1600. doi: 10.1038/s41467-017-01571-8. Nat Commun. 2017. PMID: 29150604 Free PMC article.
4,179 results