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6,798 results
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Targeting the EGFR-family for therapy: biological challenges and clinical perspective.
Patel R, Leung HY. Patel R, et al. Curr Pharm Des. 2012;18(19):2672-9. doi: 10.2174/138161212800626148. Curr Pharm Des. 2012. PMID: 22390755 Review.
SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis.
Gao M, Patel R, Ahmad I, Fleming J, Edwards J, McCracken S, Sahadevan K, Seywright M, Norman J, Sansom O, Leung HY. Gao M, et al. Among authors: patel r. EMBO Mol Med. 2012 Aug;4(8):776-90. doi: 10.1002/emmm.201100944. Epub 2012 May 31. EMBO Mol Med. 2012. PMID: 22649008 Free PMC article.
Modelling synergistic interactions between HER2, Sprouty2 and PTEN in driving prostate carcinogenesis.
Ahmad I, Gao M, Patel R, Leung HY. Ahmad I, et al. Among authors: patel r. Asian J Androl. 2013 May;15(3):323-7. doi: 10.1038/aja.2013.40. Epub 2013 Apr 15. Asian J Androl. 2013. PMID: 23584380 Free PMC article. No abstract available.
Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation.
Mardilovich K, Gabrielsen M, McGarry L, Orange C, Patel R, Shanks E, Edwards J, Olson MF. Mardilovich K, et al. Among authors: patel r. Mol Cancer Ther. 2015 Jan;14(1):246-58. doi: 10.1158/1535-7163.MCT-14-0447. Epub 2014 Oct 24. Mol Cancer Ther. 2015. PMID: 25344584 Free PMC article.
Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.
Patel R, Fleming J, Mui E, Loveridge C, Repiscak P, Blomme A, Harle V, Salji M, Ahmad I, Teo K, Hamdy FC, Hedley A, van den Broek N, Mackay G, Edwards J, Sansom OJ, Leung HY. Patel R, et al. EMBO Mol Med. 2018 Apr;10(4):e8347. doi: 10.15252/emmm.201708347. EMBO Mol Med. 2018. PMID: 29540470 Free PMC article.
HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer.
Ahmad I, Patel R, Singh LB, Nixon C, Seywright M, Barnetson RJ, Brunton VG, Muller WJ, Edwards J, Sansom OJ, Leung HY. Ahmad I, et al. Among authors: patel r. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16392-7. doi: 10.1073/pnas.1101263108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930937 Free PMC article.
Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.
Ahmad I, Mui E, Galbraith L, Patel R, Tan EH, Salji M, Rust AG, Repiscak P, Hedley A, Markert E, Loveridge C, van der Weyden L, Edwards J, Sansom OJ, Adams DJ, Leung HY. Ahmad I, et al. Among authors: patel r. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8290-5. doi: 10.1073/pnas.1601571113. Epub 2016 Jun 29. Proc Natl Acad Sci U S A. 2016. PMID: 27357679 Free PMC article.
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.
Patel R, Gao M, Ahmad I, Fleming J, Singh LB, Rai TS, McKie AB, Seywright M, Barnetson RJ, Edwards J, Sansom OJ, Leung HY. Patel R, et al. J Clin Invest. 2013 Mar;123(3):1157-75. doi: 10.1172/JCI63672. Epub 2013 Feb 22. J Clin Invest. 2013. PMID: 23434594 Free PMC article.
Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment.
Rushworth LK, Hewit K, Munnings-Tomes S, Somani S, James D, Shanks E, Dufès C, Straube A, Patel R, Leung HY. Rushworth LK, et al. Among authors: patel r. Br J Cancer. 2020 Feb;122(4):517-527. doi: 10.1038/s41416-019-0681-5. Epub 2019 Dec 17. Br J Cancer. 2020. PMID: 31844184 Free PMC article.
Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer.
Patel R, Brzezinska EA, Repiscak P, Ahmad I, Mui E, Gao M, Blomme A, Harle V, Tan EH, Malviya G, Mrowinska A, Loveridge CJ, Rushworth LK, Edwards J, Ntala C, Nixon C, Hedley A, Mackay G, Tardito S, Sansom OJ, Leung HY. Patel R, et al. Cancer Res. 2020 Feb 1;80(3):576-590. doi: 10.1158/0008-5472.CAN-19-1684. Epub 2019 Nov 12. Cancer Res. 2020. PMID: 31719098
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