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Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.
Mouchantaf R, Watt HL, Sulea T, Seidah NG, Alturaihi H, Patel YC, Kumar U. Mouchantaf R, et al. Among authors: patel yc. Regul Pept. 2004 Aug 15;120(1-3):133-40. doi: 10.1016/j.regpep.2004.02.022. Regul Pept. 2004. PMID: 15177931
Somatostatin and its receptor family.
Patel YC. Patel YC. Front Neuroendocrinol. 1999 Jul;20(3):157-98. doi: 10.1006/frne.1999.0183. Front Neuroendocrinol. 1999. PMID: 10433861 Review.
Developmental changes in the expression of somatostatin receptors (1-5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus.
Goodyer CG, Grigorakis SI, Patel YC, Kumar U. Goodyer CG, et al. Among authors: patel yc. Neuroscience. 2004;125(2):441-8. doi: 10.1016/j.neuroscience.2004.02.001. Neuroscience. 2004. PMID: 15062986
Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.
Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, Patel YC. Rocheville M, et al. J Biol Chem. 2000 Mar 17;275(11):7862-9. doi: 10.1074/jbc.275.11.7862. J Biol Chem. 2000. PMID: 10713101
The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.
Hukovic N, Panetta R, Kumar U, Rocheville M, Patel YC. Hukovic N, et al. J Biol Chem. 1998 Aug 14;273(33):21416-22. doi: 10.1074/jbc.273.33.21416. J Biol Chem. 1998. PMID: 9694905
A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.
Corness JD, Demchyshyn LL, Seeman P, Van Tol HH, Srikant CB, Kent G, Patel YC, Niznik HB. Corness JD, et al. FEBS Lett. 1993 Apr 26;321(2-3):279-84. doi: 10.1016/0014-5793(93)80124-d. FEBS Lett. 1993. PMID: 8097479
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