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2004 1
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Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging.
Ciccarelli O, Barkhof F, Bodini B, De Stefano N, Golay X, Nicolay K, Pelletier D, Pouwels PJ, Smith SA, Wheeler-Kingshott CA, Stankoff B, Yousry T, Miller DH. Ciccarelli O, et al. Lancet Neurol. 2014 Aug;13(8):807-22. doi: 10.1016/S1474-4422(14)70101-2. Epub 2014 Jul 6. Lancet Neurol. 2014. PMID: 25008549 Review.
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated and progressive disability. Disease mechanisms can be investigated in preclinical models and patients with multiple sclerosis by …
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated an …
Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.
Beaino W, Janssen B, Kooij G, van der Pol SMA, van Het Hof B, van Horssen J, Windhorst AD, de Vries HE. Beaino W, et al. J Neuroinflammation. 2017 Dec 22;14(1):259. doi: 10.1186/s12974-017-1034-z. J Neuroinflammation. 2017. PMID: 29273052 Free PMC article.
BACKGROUND: Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. ...Ultimately, this may provide insight into the role of microglia in disease progression and monitor novel treatmen …
BACKGROUND: Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in dise …
Integration of metabolomics and proteomics in multiple sclerosis: From biomarkers discovery to personalized medicine.
Del Boccio P, Rossi C, di Ioia M, Cicalini I, Sacchetta P, Pieragostino D. Del Boccio P, et al. Proteomics Clin Appl. 2016 Apr;10(4):470-84. doi: 10.1002/prca.201500083. Epub 2016 Mar 11. Proteomics Clin Appl. 2016. PMID: 27061322 Review.
These considerations have more value in case of multiple sclerosis (MuS), a multifactorial disease with high heterogeneity in clinical course and treatment response. ...In conclusion, the integration of Metabolomics and Proteomics may allow a more complete character …
These considerations have more value in case of multiple sclerosis (MuS), a multifactorial disease with high heterogeneity in …
Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression.
Ewing E, Kular L, Fernandes SJ, Karathanasis N, Lagani V, Ruhrmann S, Tsamardinos I, Tegner J, Piehl F, Gomez-Cabrero D, Jagodic M. Ewing E, et al. EBioMedicine. 2019 May;43:411-423. doi: 10.1016/j.ebiom.2019.04.042. Epub 2019 Apr 30. EBioMedicine. 2019. PMID: 31053557 Free PMC article.
BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory disease and a leading cause of progressive neurological disability among young adults. DNA methylation, which intersects genes and environment to control cellular functions on a molecular level, ma …
BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory disease and a leading cause of progressive neurological disabili …
The clinical potential of blood-proteomics in multiple sclerosis.
De Masi R, Pasca S, Scarpello R, Idolo A, De Donno A. De Masi R, et al. BMC Neurol. 2013 May 21;13:45. doi: 10.1186/1471-2377-13-45. BMC Neurol. 2013. PMID: 23692923 Free PMC article.
BACKGROUND: The aetiology of multiple sclerosis (MS) remains unknown. This hampers molecular diagnosis and the discovery of bio-molecular markers. ...The functional profile of the identified molecules provides new pathophysiological insight into …
BACKGROUND: The aetiology of multiple sclerosis (MS) remains unknown. This hampers molecular diagnosis and the discover …
Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw.
Raje N, Woo SB, Hande K, Yap JT, Richardson PG, Vallet S, Treister N, Hideshima T, Sheehy N, Chhetri S, Connell B, Xie W, Tai YT, Szot-Barnes A, Tian M, Schlossman RL, Weller E, Munshi NC, Van Den Abbeele AD, Anderson KC. Raje N, et al. Clin Cancer Res. 2008 Apr 15;14(8):2387-95. doi: 10.1158/1078-0432.CCR-07-1430. Clin Cancer Res. 2008. PMID: 18413829 Free article.
This study was conducted in order to define ONJ clinically and radiographically and gain insights into its pathophysiology. EXPERIMENTAL DESIGN: Eleven multiple myeloma (MM) patients with ONJ were included in the study. Patients underwent clinical, biochemical, radi …
This study was conducted in order to define ONJ clinically and radiographically and gain insights into its pathophysiology. EXPERIMEN …
Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients.
Eggers EL, Michel BA, Wu H, Wang SZ, Bevan CJ, Abounasr A, Pierson NS, Bischof A, Kazer M, Leitner E, Greenfield AL, Demuth S, Wilson MR, Henry RG, Cree BA, Hauser SL, von Büdingen HC. Eggers EL, et al. JCI Insight. 2017 Nov 16;2(22):e92724. doi: 10.1172/jci.insight.92724. eCollection 2017 Nov 16. JCI Insight. 2017. PMID: 29202449 Free PMC article.
A role of B cells in multiple sclerosis (MS) is well established, but there is limited understanding of their involvement during active disease. ...
A role of B cells in multiple sclerosis (MS) is well established, but there is limited understanding of their involvement duri …
Molecular mechanisms linking neuroinflammation and neurodegeneration in MS.
Ellwardt E, Zipp F. Ellwardt E, et al. Exp Neurol. 2014 Dec;262 Pt A:8-17. doi: 10.1016/j.expneurol.2014.02.006. Epub 2014 Feb 14. Exp Neurol. 2014. PMID: 24530639 Review.
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central nervous system (CNS) and one of the leading causes of neurological deficits and disability in young adults in western countries. ...Experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central nervous system (CNS) and one of th
Corticohippocampal Dysfunction In The OBiden Mouse Model Of Primary Oligodendrogliopathy.
Radecki DZ, Johnson EL, Brown AK, Meshkin NT, Perrine SA, Gow A. Radecki DZ, et al. Sci Rep. 2018 Oct 31;8(1):16116. doi: 10.1038/s41598-018-34414-7. Sci Rep. 2018. PMID: 30382234 Free PMC article.
Despite concerted efforts over decades, the etiology of multiple sclerosis (MS) remains unclear. Autoimmunity, environmental-challenges, molecular mimicry and viral hypotheses have proven equivocal because early-stage disease is typically presymptomati …
Despite concerted efforts over decades, the etiology of multiple sclerosis (MS) remains unclear. Autoimmunity, environm …
Role of cytosolic calcium-dependent phospholipase A2 in Alzheimer's disease pathogenesis.
Gentile MT, Reccia MG, Sorrentino PP, Vitale E, Sorrentino G, Puca AA, Colucci-D'Amato L. Gentile MT, et al. Mol Neurobiol. 2012 Jun;45(3):596-604. doi: 10.1007/s12035-012-8279-4. Epub 2012 May 31. Mol Neurobiol. 2012. PMID: 22648535 Review.
PLA2s have been so far considered a crucial element in the etiopathogenesis of several neurological diseases such as cerebral ischemia, multiple sclerosis, Parkinson's disease, and Alzheimer's disease (AD). ...In this review, we have focused on the …
PLA2s have been so far considered a crucial element in the etiopathogenesis of several neurological diseases such as cerebral ischemia, m
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