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Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging.
Ciccarelli O, Barkhof F, Bodini B, De Stefano N, Golay X, Nicolay K, Pelletier D, Pouwels PJ, Smith SA, Wheeler-Kingshott CA, Stankoff B, Yousry T, Miller DH. Ciccarelli O, et al. Lancet Neurol. 2014 Aug;13(8):807-22. doi: 10.1016/S1474-4422(14)70101-2. Epub 2014 Jul 6. Lancet Neurol. 2014. PMID: 25008549 Review.
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated and progressive disability. Disease mechanisms can be investigated in preclinical models and patients with multiple sclerosis by …
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated an …
Integration of metabolomics and proteomics in multiple sclerosis: From biomarkers discovery to personalized medicine.
Del Boccio P, Rossi C, di Ioia M, Cicalini I, Sacchetta P, Pieragostino D. Del Boccio P, et al. Proteomics Clin Appl. 2016 Apr;10(4):470-84. doi: 10.1002/prca.201500083. Epub 2016 Mar 11. Proteomics Clin Appl. 2016. PMID: 27061322 Review.
In the last decade, advances in high-throughput approaches allowed the development of proteomic and metabolomic studies in evaluating the association of genetic and phenotypic variability with disease sensitivity and analgesic response. These considerations have more value in cas …
In the last decade, advances in high-throughput approaches allowed the development of proteomic and metabolomic studies in evaluating the as …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic proc …
Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophag …
Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.
Beaino W, Janssen B, Kooij G, van der Pol SMA, van Het Hof B, van Horssen J, Windhorst AD, de Vries HE. Beaino W, et al. J Neuroinflammation. 2017 Dec 22;14(1):259. doi: 10.1186/s12974-017-1034-z. J Neuroinflammation. 2017. PMID: 29273052 Free PMC article.
BACKGROUND: Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. ...Little is known about in vivo dynamics of microglia phenotypes in MS due to the lack of diagnostic tools. Positron emiss …
BACKGROUND: Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in dise …
Molecular mechanisms linking neuroinflammation and neurodegeneration in MS.
Ellwardt E, Zipp F. Ellwardt E, et al. Exp Neurol. 2014 Dec;262 Pt A:8-17. doi: 10.1016/j.expneurol.2014.02.006. Epub 2014 Feb 14. Exp Neurol. 2014. PMID: 24530639 Review.
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central nervous system (CNS) and one of the leading causes of neurological deficits and disability in young adults in western countries. ...Experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central nervous system (CNS) and one of th
Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models.
Kosillo P, Bateup HS. Kosillo P, et al. Front Neural Circuits. 2021 Jul 23;15:700968. doi: 10.3389/fncir.2021.700968. eCollection 2021. Front Neural Circuits. 2021. PMID: 34366796 Free PMC article. Review.
The midbrain dopamine system is an important modulator of cellular and synaptic function in multiple ASD-implicated brain regions via anatomically and functionally distinct dopaminergic projections. ...We discuss the human literature supporting the involvement of altered d …
The midbrain dopamine system is an important modulator of cellular and synaptic function in multiple ASD-implicated brain regions via …
Multiple Sclerosis Biomarker Candidates Revealed by Cell-Type-Specific Interactome Analysis.
Yurduseven K, Babal YK, Celik E, Kerman BE, Kurnaz IA. Yurduseven K, et al. OMICS. 2022 May;26(5):305-317. doi: 10.1089/omi.2022.0023. Epub 2022 Apr 27. OMICS. 2022. PMID: 35483054
Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. ...From a study design and methodology perspective, we suggest that the cell-type-specific intera
Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY. Liu S, et al. Nat Commun. 2022 Feb 8;13(1):731. doi: 10.1038/s41467-022-28417-2. Nat Commun. 2022. PMID: 35136060 Free PMC article.
Here we report single-particle cryo-EM structures of human S1P receptor 1 (S1P(1)) and heterotrimeric G(i) complexes formed with bound S1P or the multiple sclerosis (MS) treatment drug Siponimod, as well as human LPA receptor 1 (LPA(1)) and G(i) complexes in the pre …
Here we report single-particle cryo-EM structures of human S1P receptor 1 (S1P(1)) and heterotrimeric G(i) complexes formed with bound S1P o …
Role of cytosolic calcium-dependent phospholipase A2 in Alzheimer's disease pathogenesis.
Gentile MT, Reccia MG, Sorrentino PP, Vitale E, Sorrentino G, Puca AA, Colucci-D'Amato L. Gentile MT, et al. Mol Neurobiol. 2012 Jun;45(3):596-604. doi: 10.1007/s12035-012-8279-4. Epub 2012 May 31. Mol Neurobiol. 2012. PMID: 22648535 Review.
PLA2s have been so far considered a crucial element in the etiopathogenesis of several neurological diseases such as cerebral ischemia, multiple sclerosis, Parkinson's disease, and Alzheimer's disease (AD). ...In this review, we have focused on the molecular
PLA2s have been so far considered a crucial element in the etiopathogenesis of several neurological diseases such as cerebral ischemia, m
PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders.
Doorduin J, de Vries EF, Dierckx RA, Klein HC. Doorduin J, et al. Curr Pharm Des. 2008;14(31):3297-315. doi: 10.2174/138161208786549443. Curr Pharm Des. 2008. PMID: 19075709 Review.
It is important to gain more insight into neurodegenerative diseases, because these debilitating diseases can not be cured. ...However, the potential of these new PBR ligands is still under investigation and as a consequence [(11)C]PK11195 is used so far to image ac …
It is important to gain more insight into neurodegenerative diseases, because these debilitating diseases can not be cured. ...Howeve …
24 results