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Pathomechanisms of discogenic low back pain in humans and animal models.
Ohtori S, Inoue G, Miyagi M, Takahashi K. Ohtori S, et al. Spine J. 2015 Jun 1;15(6):1347-55. doi: 10.1016/j.spinee.2013.07.490. Epub 2014 Mar 20. Spine J. 2015. PMID: 24657737 Review.
BACKGROUND CONTEXT: Although explored in humans and animal models, the pathomechanisms of discogenic low back pain (LBP) remain unknown. PURPOSE: The aim of this study was to review the literature about the pathomechanism
BACKGROUND CONTEXT: Although explored in humans and animal models, the pathomechanisms of discogenic l
ISSLS prize winner: disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: a pathomechanism for chronic discogenic low back pain.
Miyagi M, Ishikawa T, Kamoda H, Suzuki M, Murakami K, Shibayama M, Orita S, Eguchi Y, Arai G, Sakuma Y, Kubota G, Oikawa Y, Ozawa T, Aoki Y, Toyone T, Takahashi K, Inoue G, Kawakami M, Ohtori S. Miyagi M, et al. Spine (Phila Pa 1976). 2012 Oct 1;37(21):1810-8. doi: 10.1097/BRS.0b013e31824ffac6. Spine (Phila Pa 1976). 2012. PMID: 22366969
STUDY DESIGN: Animal model of intravertebral disc (IVD) degeneration. OBJECTIVE: To examine production of inflammatory mediators in IVDs and neuropeptides in dorsal root ganglia (DRGs) in rat models of IVD compression and injury. SUMMARY OF BACKGROUND DATA: Sensory …
STUDY DESIGN: Animal model of intravertebral disc (IVD) degeneration. OBJECTIVE: To examine production of inflammatory mediators in I …