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Year Number of Results
2009 3
2011 3
2012 4
2013 5
2014 4
2015 2
2016 5
2017 6
2018 4
2019 1
2020 5
2021 1
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Pathway inhibition: emerging molecular targets for treating glioblastoma.
Wick W, Weller M, Weiler M, Batchelor T, Yung AW, Platten M. Wick W, et al. Neuro Oncol. 2011 Jun;13(6):566-79. doi: 10.1093/neuonc/nor039. Neuro Oncol. 2011. PMID: 21636705 Free PMC article. Review.
Therefore, the identification of novel molecular targets and inhibitory agents has become a focus of research for glioblastoma treatment. ...This review discusses limitations in the existing therapy for glioblastoma and provides an overview of c …
Therefore, the identification of novel molecular targets and inhibitory agents has become a focus of research for glioblast
Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.
Kudinov AE, Karanicolas J, Golemis EA, Boumber Y. Kudinov AE, et al. Clin Cancer Res. 2017 May 1;23(9):2143-2153. doi: 10.1158/1078-0432.CCR-16-2728. Epub 2017 Jan 31. Clin Cancer Res. 2017. PMID: 28143872 Free PMC article. Review.
More recently, the Musashi proteins were found to be overexpressed and prognostic of outcome in numerous cancer types, including colorectal, lung, and pancreatic cancers; glioblastoma; and several leukemias. MSI1 and MSI2 bind and regulate the mRNA stability and translatio …
More recently, the Musashi proteins were found to be overexpressed and prognostic of outcome in numerous cancer types, including colorectal, …
Targeting notch signaling pathway in cancer: clinical development advances and challenges.
Takebe N, Nguyen D, Yang SX. Takebe N, et al. Pharmacol Ther. 2014 Feb;141(2):140-9. doi: 10.1016/j.pharmthera.2013.09.005. Epub 2013 Sep 27. Pharmacol Ther. 2014. PMID: 24076266 Free PMC article. Review.
A number of mechanism-based adverse events particularly gastrointestinal toxicities emerged and mitigation strategies are developed after testing multiple GSIs and Notch targeting mAbs. We also discuss pharmacodynamic biomarkers in conjunction with methods of assess …
A number of mechanism-based adverse events particularly gastrointestinal toxicities emerged and mitigation strategies are developed a …
TGF-beta2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion.
Zhang C, Zhang X, Xu R, Huang B, Chen AJ, Li C, Wang J, Li XG. Zhang C, et al. J Exp Clin Cancer Res. 2017 Nov 16;36(1):162. doi: 10.1186/s13046-017-0628-8. J Exp Clin Cancer Res. 2017. PMID: 29145888 Free PMC article.
BACKGROUND: Glioblastoma multiforme (GBM) is characterized by lethal aggressiveness and patients with GBM are in urgent need for new therapeutic avenues to improve quality of life. ...Western blot, qPCR, immunofluorescence and transmission-electron microscope were used to …
BACKGROUND: Glioblastoma multiforme (GBM) is characterized by lethal aggressiveness and patients with GBM are in urgent need for new …
Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.
Lafita-Navarro MC, Venkateswaran N, Kilgore JA, Kanji S, Han J, Barnes S, Williams NS, Buszczak M, Burma S, Conacci-Sorrell M. Lafita-Navarro MC, et al. PLoS Genet. 2020 Nov 17;16(11):e1009117. doi: 10.1371/journal.pgen.1009117. eCollection 2020 Nov. PLoS Genet. 2020. PMID: 33201894 Free PMC article.
Metabolic adaptations leading to increased synthesis of nucleotides by de novo biosynthesis pathways are emerging as key alterations driving glioblastoma growth. ...Our study demonstrates that glioblastoma cells heavily rely on the de novo pyrimidine b …
Metabolic adaptations leading to increased synthesis of nucleotides by de novo biosynthesis pathways are emerging as key alter …
Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances.
Mastrangelopoulou M, Grigalavicius M, Raabe TH, Skarpen E, Juzenas P, Peng Q, Berg K, Theodossiou TA. Mastrangelopoulou M, et al. Cancer Rep (Hoboken). 2020 Jul 31:e1278. doi: 10.1002/cnr2.1278. Online ahead of print. Cancer Rep (Hoboken). 2020. PMID: 32737955 Free article.
BACKGROUND: Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies. 5-aminolevulinic acid (5-ALA)-PDT is of particular interest, as it uses the photosensitiser PpIX, naturally p …
BACKGROUND: Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over othe …
Epidermal growth factor receptor: a re-emerging target in glioblastoma.
Hegi ME, Rajakannu P, Weller M. Hegi ME, et al. Curr Opin Neurol. 2012 Dec;25(6):774-9. doi: 10.1097/WCO.0b013e328359b0bc. Curr Opin Neurol. 2012. PMID: 23007009 Review.
Here, we review recent insights into molecular mechanisms relevant for effective targeting of the EGFR pathway. ...SUMMARY: A combination of preclinical and clinical studies at the molecular level has provided new insights that will allow refining stra …
Here, we review recent insights into molecular mechanisms relevant for effective targeting of the EGFR pathway. ...SUMM …
Emerging therapeutic potential of anti-psychotic drugs in the management of human glioma: A comprehensive review.
Kamarudin MNA, Parhar I. Kamarudin MNA, et al. Oncotarget. 2019 Jun 11;10(39):3952-3977. doi: 10.18632/oncotarget.26994. eCollection 2019 Jun 11. Oncotarget. 2019. PMID: 31231472 Free PMC article. Review.
Despite numerous advancements in the last decade, human gliomas such as astrocytoma and glioblastoma multiforme have the worst prognoses among all cancers. Anti-psychotic drugs are commonly prescribed to treat mental disorders among cancer patients, and growing empi …
Despite numerous advancements in the last decade, human gliomas such as astrocytoma and glioblastoma multiforme have the worst progno …
Epidermal growth factor receptor targeting and challenges in glioblastoma.
Thorne AH, Zanca C, Furnari F. Thorne AH, et al. Neuro Oncol. 2016 Jul;18(7):914-8. doi: 10.1093/neuonc/nov319. Epub 2016 Jan 10. Neuro Oncol. 2016. PMID: 26755074 Free PMC article. Review.
Greater characterization of glioblastoma at the molecular level has improved its initial pathophysiological staging and classification. ...In this review, we provide a brief overview of EGFR and its mutated form, EGFR variant III, describing the downstream cellular …
Greater characterization of glioblastoma at the molecular level has improved its initial pathophysiological staging and classi …
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta.
Miyashita K, Nakada M, Shakoori A, Ishigaki Y, Shimasaki T, Motoo Y, Kawakami K, Minamoto T. Miyashita K, et al. Anticancer Agents Med Chem. 2009 Dec;9(10):1114-22. doi: 10.2174/187152009789734982. Anticancer Agents Med Chem. 2009. PMID: 19925395 Review.
Improvement in the outcome of cancer patients who are refractory to currently available treatments relies on the development of target-directed therapies. One group of molecular targets with potential clinical relevance is a set of protein tyrosine kinases en …
Improvement in the outcome of cancer patients who are refractory to currently available treatments relies on the development of target
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