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The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
Greenhough A, Patsos HA, Williams AC, Paraskeva C. Greenhough A, et al. Among authors: patsos ha. Int J Cancer. 2007 Nov 15;121(10):2172-80. doi: 10.1002/ijc.22917. Int J Cancer. 2007. PMID: 17583570 Free article.
The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells.
Collard TJ, Urban BC, Patsos HA, Hague A, Townsend PA, Paraskeva C, Williams AC. Collard TJ, et al. Among authors: patsos ha. Cell Death Dis. 2012 Oct 11;3(10):e408. doi: 10.1038/cddis.2012.142. Cell Death Dis. 2012. PMID: 23059827 Free PMC article.
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2.
Patsos HA, Hicks DJ, Dobson RR, Greenhough A, Woodman N, Lane JD, Williams AC, Paraskeva C. Patsos HA, et al. Gut. 2005 Dec;54(12):1741-50. doi: 10.1136/gut.2005.073403. Epub 2005 Aug 11. Gut. 2005. PMID: 16099783 Free PMC article.
Prospects in NSAID-derived chemoprevention of colorectal cancer.
Chell S, Patsos HA, Qualtrough D, H-Zadeh AM, Hicks DJ, Kaidi A, Witherden IR, Williams AC, Paraskeva C. Chell S, et al. Among authors: patsos ha. Biochem Soc Trans. 2005 Aug;33(Pt 4):667-71. doi: 10.1042/BST0330667. Biochem Soc Trans. 2005. PMID: 16042570 Review.
Cannabinoids and cancer: potential for colorectal cancer therapy.
Patsos HA, Hicks DJ, Greenhough A, Williams AC, Paraskeva C. Patsos HA, et al. Biochem Soc Trans. 2005 Aug;33(Pt 4):712-4. doi: 10.1042/BST0330712. Biochem Soc Trans. 2005. PMID: 16042581 Review.
The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.
Patsos HA, Greenhough A, Hicks DJ, Al Kharusi M, Collard TJ, Lane JD, Paraskeva C, Williams AC. Patsos HA, et al. Int J Oncol. 2010 Jul;37(1):187-93. doi: 10.3892/ijo_00000666. Int J Oncol. 2010. PMID: 20514410
HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Moore AE, Greenhough A, Roberts HR, Hicks DJ, Patsos HA, Williams AC, Paraskeva C. Moore AE, et al. Among authors: patsos ha. Carcinogenesis. 2009 Oct;30(10):1796-804. doi: 10.1093/carcin/bgp183. Epub 2009 Jul 28. Carcinogenesis. 2009. PMID: 19638428
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