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Will admixture mapping work to find disease genes?
Reich D, Patterson N. Reich D, et al. Among authors: patterson n. Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1605-7. doi: 10.1098/rstb.2005.1691. Philos Trans R Soc Lond B Biol Sci. 2005. PMID: 16096110 Free PMC article. Review.
Methods for high-density admixture mapping of disease genes.
Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Patterson N, et al. Am J Hum Genet. 2004 May;74(5):979-1000. doi: 10.1086/420871. Epub 2004 Apr 14. Am J Hum Genet. 2004. PMID: 15088269 Free PMC article.
A high-density admixture map for disease gene discovery in african americans.
Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De The G, Essex M, Sankale JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien SJ, Reich D. Smith MW, et al. Among authors: patterson n. Am J Hum Genet. 2004 May;74(5):1001-13. doi: 10.1086/420856. Epub 2004 Apr 14. Am J Hum Genet. 2004. PMID: 15088270 Free PMC article.
Support for involvement of neuregulin 1 in schizophrenia pathophysiology.
Petryshen TL, Middleton FA, Kirby A, Aldinger KA, Purcell S, Tahl AR, Morley CP, McGann L, Gentile KL, Rockwell GN, Medeiros HM, Carvalho C, Macedo A, Dourado A, Valente J, Ferreira CP, Patterson NJ, Azevedo MH, Daly MJ, Pato CN, Pato MT, Sklar P. Petryshen TL, et al. Among authors: patterson nj. Mol Psychiatry. 2005 Apr;10(4):366-74, 328. doi: 10.1038/sj.mp.4001608. Mol Psychiatry. 2005. PMID: 15545978 Clinical Trial.
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. Reich D, et al. Among authors: patterson n. Nat Genet. 2005 Oct;37(10):1113-8. doi: 10.1038/ng1646. Epub 2005 Sep 25. Nat Genet. 2005. PMID: 16186815
Principal components analysis corrects for stratification in genome-wide association studies.
Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Price AL, et al. Nat Genet. 2006 Aug;38(8):904-9. doi: 10.1038/ng1847. Epub 2006 Jul 23. Nat Genet. 2006. PMID: 16862161
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.
Freedman ML, Haiman CA, Patterson N, McDonald GJ, Tandon A, Waliszewska A, Penney K, Steen RG, Ardlie K, John EM, Oakley-Girvan I, Whittemore AS, Cooney KA, Ingles SA, Altshuler D, Henderson BE, Reich D. Freedman ML, et al. Among authors: patterson n. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14068-73. doi: 10.1073/pnas.0605832103. Epub 2006 Aug 31. Proc Natl Acad Sci U S A. 2006. PMID: 16945910 Free PMC article.
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.
Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris T, Zmuda JM, Ziv E; Health, Aging and Body Composition (Health ABC) Study. Reich D, et al. Among authors: patterson n. Am J Hum Genet. 2007 Apr;80(4):716-26. doi: 10.1086/513206. Epub 2007 Mar 8. Am J Hum Genet. 2007. PMID: 17357077 Free PMC article.
A genomewide admixture map for Latino populations.
Price AL, Patterson N, Yu F, Cox DR, Waliszewska A, McDonald GJ, Tandon A, Schirmer C, Neubauer J, Bedoya G, Duque C, Villegas A, Bortolini MC, Salzano FM, Gallo C, Mazzotti G, Tello-Ruiz M, Riba L, Aguilar-Salinas CA, Canizales-Quinteros S, Menjivar M, Klitz W, Henderson B, Haiman CA, Winkler C, Tusie-Luna T, Ruiz-Linares A, Reich D. Price AL, et al. Among authors: patterson n. Am J Hum Genet. 2007 Jun;80(6):1024-36. doi: 10.1086/518313. Epub 2007 Apr 13. Am J Hum Genet. 2007. PMID: 17503322 Free PMC article.
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.
Ayodo G, Price AL, Keinan A, Ajwang A, Otieno MF, Orago AS, Patterson N, Reich D. Ayodo G, et al. Among authors: patterson n. Am J Hum Genet. 2007 Aug;81(2):234-42. doi: 10.1086/519221. Epub 2007 Jun 15. Am J Hum Genet. 2007. PMID: 17668374 Free PMC article.
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