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Population structure and eigenanalysis.
Patterson N, Price AL, Reich D. Patterson N, et al. PLoS Genet. 2006 Dec;2(12):e190. doi: 10.1371/journal.pgen.0020190. PLoS Genet. 2006. PMID: 17194218 Free PMC article.
Detecting recent positive selection in the human genome from haplotype structure.
Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES. Sabeti PC, et al. Among authors: patterson nj. Nature. 2002 Oct 24;419(6909):832-7. doi: 10.1038/nature01140. Epub 2002 Oct 9. Nature. 2002. PMID: 12397357
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. Mootha VK, et al. Among authors: patterson n. Nat Genet. 2003 Jul;34(3):267-73. doi: 10.1038/ng1180. Nat Genet. 2003. PMID: 12808457
Assessing the impact of population stratification on genetic association studies.
Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D. Freedman ML, et al. Among authors: patterson n. Nat Genet. 2004 Apr;36(4):388-93. doi: 10.1038/ng1333. Epub 2004 Mar 28. Nat Genet. 2004. PMID: 15052270
Methods for high-density admixture mapping of disease genes.
Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Patterson N, et al. Am J Hum Genet. 2004 May;74(5):979-1000. doi: 10.1086/420871. Epub 2004 Apr 14. Am J Hum Genet. 2004. PMID: 15088269 Free PMC article.
Genetic signatures of strong recent positive selection at the lactase gene.
Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN. Bersaglieri T, et al. Among authors: patterson n. Am J Hum Genet. 2004 Jun;74(6):1111-20. doi: 10.1086/421051. Epub 2004 Apr 26. Am J Hum Genet. 2004. PMID: 15114531 Free PMC article.
How old is the most recent ancestor of two copies of an allele?
Patterson NJ. Patterson NJ. Genetics. 2005 Feb;169(2):1093-104. doi: 10.1534/genetics.103.015768. Epub 2004 Nov 1. Genetics. 2005. PMID: 15520271 Free PMC article.
In particular, we show that the expected age of the MRCA of two copies of an allele with population frequency f is just 2Nf generations, where N is the effective population size. ...
In particular, we show that the expected age of the MRCA of two copies of an allele with population frequency f is just 2Nf generations, whe …
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. Reich D, et al. Among authors: patterson n. Nat Genet. 2005 Oct;37(10):1113-8. doi: 10.1038/ng1646. Epub 2005 Sep 25. Nat Genet. 2005. PMID: 16186815
The case for selection at CCR5-Delta32.
Sabeti PC, Walsh E, Schaffner SF, Varilly P, Fry B, Hutcheson HB, Cullen M, Mikkelsen TS, Roy J, Patterson N, Cooper R, Reich D, Altshuler D, O'Brien S, Lander ES. Sabeti PC, et al. Among authors: patterson n. PLoS Biol. 2005 Nov;3(11):e378. doi: 10.1371/journal.pbio.0030378. Epub 2005 Nov 1. PLoS Biol. 2005. PMID: 16248677 Free PMC article.
Genetic evidence for complex speciation of humans and chimpanzees.
Patterson N, Richter DJ, Gnerre S, Lander ES, Reich D. Patterson N, et al. Nature. 2006 Jun 29;441(7097):1103-8. doi: 10.1038/nature04789. Epub 2006 May 17. Nature. 2006. PMID: 16710306
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