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Sleep-disordered breathing in newborn mice heterozygous for the transcription factor Phox2b.
Durand E, Dauger S, Pattyn A, Gaultier C, Goridis C, Gallego J. Durand E, et al. Am J Respir Crit Care Med. 2005 Jul 15;172(2):238-43. doi: 10.1164/rccm.200411-1528OC. Epub 2005 Apr 28. Am J Respir Crit Care Med. 2005. PMID: 15860752
RATIONALE: Central congenital hypoventilation syndrome (CCHS) is a rare autosomal dominant syndrome present from birth, and characterized by depressed ventilation during sleep. Heterozygous mutations of the homeobox gene Phox2b were recently found in a very high pro …
RATIONALE: Central congenital hypoventilation syndrome (CCHS) is a rare autosomal dominant syndrome present from birth, and character …
Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.
Dauger S, Pattyn A, Lofaso F, Gaultier C, Goridis C, Gallego J, Brunet JF. Dauger S, et al. Development. 2003 Dec;130(26):6635-42. doi: 10.1242/dev.00866. Epub 2003 Nov 19. Development. 2003. PMID: 14627719
We report that the afferent relays of visceral (cardiovascular, digestive and respiratory) reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as d …
We report that the afferent relays of visceral (cardiovascular, digestive and respiratory) reflexes, differentiate under the control of the …
Phox2 genes - from patterning to connectivity.
Brunet JF, Pattyn A. Brunet JF, et al. Curr Opin Genet Dev. 2002 Aug;12(4):435-40. doi: 10.1016/s0959-437x(02)00322-2. Curr Opin Genet Dev. 2002. PMID: 12100889 Review.
Ascl1/Mash1 is required for the development of central serotonergic neurons.
Pattyn A, Simplicio N, van Doorninck JH, Goridis C, Guillemot F, Brunet JF. Pattyn A, et al. Nat Neurosci. 2004 Jun;7(6):589-95. doi: 10.1038/nn1247. Epub 2004 May 9. Nat Neurosci. 2004. PMID: 15133515
Here we show in the mouse that Ascl1 is essential for the birth of 5-HT neurons, both as a proneural gene for the production of postmitotic neuronal precursors and as a determinant of the serotonergic phenotype for the parallel activation of Gata3, Lmx1b and Pet1. T …
Here we show in the mouse that Ascl1 is essential for the birth of 5-HT neurons, both as a proneural gene for the production of postm …
Essential role of Gata transcription factors in sympathetic neuron development.
Tsarovina K, Pattyn A, Stubbusch J, Müller F, van der Wees J, Schneider C, Brunet JF, Rohrer H. Tsarovina K, et al. Development. 2004 Oct;131(19):4775-86. doi: 10.1242/dev.01370. Epub 2004 Aug 25. Development. 2004. PMID: 15329349
Loss-of-function experiments resulted in a strong reduction in the size of the sympathetic chain and in decreased Th expression. Ectopic expression of Gata2 in chick neural crest precursors elicited the generation of neurons with a non-autonomic, Th-negative phenoty …
Loss-of-function experiments resulted in a strong reduction in the size of the sympathetic chain and in decreased Th expression. Ecto …
Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.
Ohayon D, Ventéo S, Sonrier C, Lafon PA, Garcès A, Valmier J, Rivat C, Topilko P, Carroll P, Pattyn A. Ohayon D, et al. Dev Cell. 2015 May 4;33(3):343-50. doi: 10.1016/j.devcel.2015.03.021. Dev Cell. 2015. PMID: 25942625
We show here that transgenic mice expressing a Zeb1/2 dominant-negative form (DBZEB) exhibit reduced numbers of nociceptors and altered pain sensitivity. ...Altogether, our results uncover roles for Zeb family members in the developing DRGs; they show that the Neurog1-depe …
We show here that transgenic mice expressing a Zeb1/2 dominant-negative form (DBZEB) exhibit reduced numbers of nociceptors and alter …
Delays in neuronal differentiation in Mash1/Ascl1 mutants.
Pattyn A, Guillemot F, Brunet JF. Pattyn A, et al. Dev Biol. 2006 Jul 1;295(1):67-75. doi: 10.1016/j.ydbio.2006.03.008. Epub 2006 May 4. Dev Biol. 2006. PMID: 16677628
The inactivation of a developmental transcription factor may lead to the complete absence of a specific cell type. More commonly, though, it only partially impairs its generation. ...Here, we report a novel function for the bHLH transcription factor Ascl1/Mas …
The inactivation of a developmental transcription factor may lead to the complete absence of a specific cell type. More common …
The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity.
Dubreuil V, Hirsch MR, Pattyn A, Brunet JF, Goridis C. Dubreuil V, et al. Development. 2000 Dec;127(23):5191-201. Development. 2000. PMID: 11060244
In the neurons thus generated, ectopic expression of Phox2b is sufficient to initiate a programme of motor neuronal differentiation characterised by expression of Islet1 and of the cholinergic transmitter phenotype, in line with our previous results showing that Phox2b is …
In the neurons thus generated, ectopic expression of Phox2b is sufficient to initiate a programme of motor neuronal differentiation c …
Specification of the central noradrenergic phenotype by the homeobox gene Phox2b.
Pattyn A, Goridis C, Brunet JF. Pattyn A, et al. Mol Cell Neurosci. 2000 Mar;15(3):235-43. doi: 10.1006/mcne.1999.0826. Mol Cell Neurosci. 2000. PMID: 10736201
Here, we report that Phox2b has a wider and overlapping role, in that it is required for the differentiation of all noradrenergic centers in the brain, including the locus coeruleus. Together with the previously reported lack of dopamine-b-hydroxylase and tyrosine hydroxyl …
Here, we report that Phox2b has a wider and overlapping role, in that it is required for the differentiation of all noradrenergic cen …
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