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Phox2 genes - from patterning to connectivity.
Brunet JF, Pattyn A. Brunet JF, et al. Among authors: pattyn a. Curr Opin Genet Dev. 2002 Aug;12(4):435-40. doi: 10.1016/s0959-437x(02)00322-2. Curr Opin Genet Dev. 2002. PMID: 12100889 Review.
Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.
Dauger S, Pattyn A, Lofaso F, Gaultier C, Goridis C, Gallego J, Brunet JF. Dauger S, et al. Among authors: pattyn a. Development. 2003 Dec;130(26):6635-42. doi: 10.1242/dev.00866. Epub 2003 Nov 19. Development. 2003. PMID: 14627719
We report that the afferent relays of visceral (cardiovascular, digestive and respiratory) reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as d …
We report that the afferent relays of visceral (cardiovascular, digestive and respiratory) reflexes, differentiate under the control of the …
Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.
Pattyn A, Vallstedt A, Dias JM, Samad OA, Krumlauf R, Rijli FM, Brunet JF, Ericson J. Pattyn A, et al. Genes Dev. 2003 Mar 15;17(6):729-37. doi: 10.1101/gad.255803. Genes Dev. 2003. PMID: 12651891 Free PMC article.
We examined the sequential generation of visceral motor neurons and serotonergic neurons from a common pool of neural progenitors located in the ventral hindbrain. ...A primary function of these proteins is to coordinate the spatial and temporal activation of the ho …
We examined the sequential generation of visceral motor neurons and serotonergic neurons from a common pool of neural progenitors loc …
Ascl1/Mash1 is required for the development of central serotonergic neurons.
Pattyn A, Simplicio N, van Doorninck JH, Goridis C, Guillemot F, Brunet JF. Pattyn A, et al. Nat Neurosci. 2004 Jun;7(6):589-95. doi: 10.1038/nn1247. Epub 2004 May 9. Nat Neurosci. 2004. PMID: 15133515
Here we show in the mouse that Ascl1 is essential for the birth of 5-HT neurons, both as a proneural gene for the production of postmitotic neuronal precursors and as a determinant of the serotonergic phenotype for the parallel activation of Gata3, Lmx1b and Pet1. T …
Here we show in the mouse that Ascl1 is essential for the birth of 5-HT neurons, both as a proneural gene for the production of postm …
Essential role of Gata transcription factors in sympathetic neuron development.
Tsarovina K, Pattyn A, Stubbusch J, Müller F, van der Wees J, Schneider C, Brunet JF, Rohrer H. Tsarovina K, et al. Among authors: pattyn a. Development. 2004 Oct;131(19):4775-86. doi: 10.1242/dev.01370. Epub 2004 Aug 25. Development. 2004. PMID: 15329349
Loss-of-function experiments resulted in a strong reduction in the size of the sympathetic chain and in decreased Th expression. Ectopic expression of Gata2 in chick neural crest precursors elicited the generation of neurons with a non-autonomic, Th-negative phenoty …
Loss-of-function experiments resulted in a strong reduction in the size of the sympathetic chain and in decreased Th expression. Ecto …
Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.
Ohayon D, Ventéo S, Sonrier C, Lafon PA, Garcès A, Valmier J, Rivat C, Topilko P, Carroll P, Pattyn A. Ohayon D, et al. Among authors: pattyn a. Dev Cell. 2015 May 4;33(3):343-50. doi: 10.1016/j.devcel.2015.03.021. Dev Cell. 2015. PMID: 25942625
We show here that transgenic mice expressing a Zeb1/2 dominant-negative form (DBZEB) exhibit reduced numbers of nociceptors and altered pain sensitivity. ...Altogether, our results uncover roles for Zeb family members in the developing DRGs; they show that the Neurog1-depe …
We show here that transgenic mice expressing a Zeb1/2 dominant-negative form (DBZEB) exhibit reduced numbers of nociceptors and alter …
Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.
Dubreuil V, Thoby-Brisson M, Rallu M, Persson K, Pattyn A, Birchmeier C, Brunet JF, Fortin G, Goridis C. Dubreuil V, et al. Among authors: pattyn a. J Neurosci. 2009 Nov 25;29(47):14836-46. doi: 10.1523/JNEUROSCI.2623-09.2009. J Neurosci. 2009. PMID: 19940179 Free PMC article.
We generated two conditional Phox2b mutations, which target different subsets of Phox2b-expressing cells, but have in common a massive depletion of RTN neurons. ...Both the rhythmic activity in the RTN region and the phrenic nerve discharges responded to a low pH ch …
We generated two conditional Phox2b mutations, which target different subsets of Phox2b-expressing cells, but have in common a massiv …
Generation and characterization of Rgs4 mutant mice.
Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF. Grillet N, et al. Among authors: pattyn a. Mol Cell Biol. 2005 May;25(10):4221-8. doi: 10.1128/MCB.25.10.4221-4228.2005. Mol Cell Biol. 2005. PMID: 15870291 Free PMC article.
RGS proteins are negative regulators of signaling through heterotrimeric G protein-coupled receptors and, as such, are in a position to regulate a plethora of biological phenomena. ...Here, we describe a mouse line deficient for Rgs4, a gene normally e …
RGS proteins are negative regulators of signaling through heterotrimeric G protein-coupled receptors and, as such, are in a position …
Delays in neuronal differentiation in Mash1/Ascl1 mutants.
Pattyn A, Guillemot F, Brunet JF. Pattyn A, et al. Dev Biol. 2006 Jul 1;295(1):67-75. doi: 10.1016/j.ydbio.2006.03.008. Epub 2006 May 4. Dev Biol. 2006. PMID: 16677628
The inactivation of a developmental transcription factor may lead to the complete absence of a specific cell type. More commonly, though, it only partially impairs its generation. ...Here, we report a novel function for the bHLH transcription factor Ascl1/Mas …
The inactivation of a developmental transcription factor may lead to the complete absence of a specific cell type. More common …
The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity.
Dubreuil V, Hirsch MR, Pattyn A, Brunet JF, Goridis C. Dubreuil V, et al. Among authors: pattyn a. Development. 2000 Dec;127(23):5191-201. Development. 2000. PMID: 11060244
In the neurons thus generated, ectopic expression of Phox2b is sufficient to initiate a programme of motor neuronal differentiation characterised by expression of Islet1 and of the cholinergic transmitter phenotype, in line with our previous results showing that Phox2b is …
In the neurons thus generated, ectopic expression of Phox2b is sufficient to initiate a programme of motor neuronal differentiation c …
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