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The insider's guide to leukocyte integrin signalling and function.
Hogg N, Patzak I, Willenbrock F. Hogg N, et al. Among authors: patzak i. Nat Rev Immunol. 2011 Jun;11(6):416-26. doi: 10.1038/nri2986. Epub 2011 May 20. Nat Rev Immunol. 2011. PMID: 21597477 Review.
Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro.
McDowall A, Svensson L, Stanley P, Patzak I, Chakravarty P, Howarth K, Sabnis H, Briones M, Hogg N. McDowall A, et al. Among authors: patzak i. Blood. 2010 Jun 10;115(23):4834-42. doi: 10.1182/blood-2009-08-238709. Epub 2010 Mar 31. Blood. 2010. PMID: 20357244
Integrins in immunity.
Evans R, Patzak I, Svensson L, De Filippo K, Jones K, McDowall A, Hogg N. Evans R, et al. Among authors: patzak i. J Cell Sci. 2009 Jan 15;122(Pt 2):215-25. doi: 10.1242/jcs.019117. J Cell Sci. 2009. PMID: 19118214 Free article. Review.
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
Svensson L, Howarth K, McDowall A, Patzak I, Evans R, Ussar S, Moser M, Metin A, Fried M, Tomlinson I, Hogg N. Svensson L, et al. Among authors: patzak i. Nat Med. 2009 Mar;15(3):306-12. doi: 10.1038/nm.1931. Epub 2009 Feb 22. Nat Med. 2009. PMID: 19234463 Free PMC article.
HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Patzak IM, Königsberger S, Suzuki A, Mak TW, Kiefer F. Patzak IM, et al. Eur J Immunol. 2010 Nov;40(11):3220-5. doi: 10.1002/eji.201040313. Eur J Immunol. 2010. PMID: 20957749 Free article.
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules.
Kliche S, Worbs T, Wang X, Degen J, Patzak I, Meineke B, Togni M, Moser M, Reinhold A, Kiefer F, Freund C, Förster R, Schraven B. Kliche S, et al. Among authors: patzak i. Blood. 2012 Jan 19;119(3):777-85. doi: 10.1182/blood-2011-06-362269. Epub 2011 Nov 23. Blood. 2012. PMID: 22117043
A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.
Reichardt P, Patzak I, Jones K, Etemire E, Gunzer M, Hogg N. Reichardt P, et al. Among authors: patzak i. EMBO J. 2013 Mar 20;32(6):829-43. doi: 10.1038/emboj.2013.33. Epub 2013 Feb 26. EMBO J. 2013. PMID: 23443048 Free PMC article.
HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.
Königsberger S, Peckl-Schmid D, Zaborsky N, Patzak I, Kiefer F, Achatz G. Königsberger S, et al. Among authors: patzak i. PLoS One. 2010 Sep 1;5(9):e12468. doi: 10.1371/journal.pone.0012468. PLoS One. 2010. PMID: 20824186 Free PMC article.
Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.
Arnold R, Patzak IM, Neuhaus B, Vancauwenbergh S, Veillette A, Van Lint J, Kiefer F. Arnold R, et al. Among authors: patzak im. Mol Cell Biol. 2005 Mar;25(6):2364-83. doi: 10.1128/MCB.25.6.2364-2383.2005. Mol Cell Biol. 2005. PMID: 15743830 Free PMC article.
A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refractory solid tumors.
Kebenko M, Goebeler ME, Wolf M, Hasenburg A, Seggewiss-Bernhardt R, Ritter B, Rautenberg B, Atanackovic D, Kratzer A, Rottman JB, Friedrich M, Vieser E, Elm S, Patzak I, Wessiepe D, Stienen S, Fiedler W. Kebenko M, et al. Among authors: patzak i. Oncoimmunology. 2018 Apr 18;7(8):e1450710. doi: 10.1080/2162402X.2018.1450710. eCollection 2018. Oncoimmunology. 2018. PMID: 30221040 Free PMC article.
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