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143 results
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Ultrasound-guided delivery of thymidine kinase-nitroreductase dual therapeutic genes by PEGylated-PLGA/PIE nanoparticles for enhanced triple negative breast cancer therapy.
Devulapally R, Lee T, Barghava-Shah A, Sekar TV, Foygel K, Bachawal SV, Willmann JK, Paulmurugan R. Devulapally R, et al. Nanomedicine (Lond). 2018 May;13(9):1051-1066. doi: 10.2217/nnm-2017-0328. Epub 2018 May 23. Nanomedicine (Lond). 2018. PMID: 29790803 Free PMC article.
Noninvasive theranostic imaging of HSV1-sr39TK-NTR/GCV-CB1954 dual-prodrug therapy in metastatic lung lesions of MDA-MB-231 triple negative breast cancer in mice.
Sekar TV, Foygel K, Ilovich O, Paulmurugan R. Sekar TV, et al. Theranostics. 2014 Feb 15;4(5):460-74. doi: 10.7150/thno.8077. eCollection 2014. Theranostics. 2014. PMID: 24669276 Free PMC article.
Noninvasive imaging of hypoxia-inducible factor-1α gene therapy for myocardial ischemia.
Chen IY, Gheysens O, Li Z, Rasooly JA, Wang Q, Paulmurugan R, Rosenberg J, Rodriguez-Porcel M, Willmann JK, Wang DS, Contag CH, Robbins RC, Wu JC, Gambhir SS. Chen IY, et al. Hum Gene Ther Methods. 2013 Oct;24(5):279-88. doi: 10.1089/hgtb.2013.028. Hum Gene Ther Methods. 2013. PMID: 23937265 Free PMC article.
Transfection of cultured HL-1 cardiomyocytes with pcTnT-HIF-1α-VP2-TSTA-fluc led to a strong correlation between FLuc and HIF-1α-dependent vascular endothelial growth factor expression (r(2)=0.88). ...
Transfection of cultured HL-1 cardiomyocytes with pcTnT-HIF-1α-VP2-TSTA-fluc led to a strong correlation between FLuc and HIF-1α-dependent v …
A novel estrogen receptor intramolecular folding-based titratable transgene expression system.
Paulmurugan R, Padmanabhan P, Ahn BC, Ray S, Willmann JK, Massoud TF, Biswal S, Gambhir SS. Paulmurugan R, et al. Mol Ther. 2009 Oct;17(10):1703-11. doi: 10.1038/mt.2009.171. Epub 2009 Aug 4. Mol Ther. 2009. PMID: 19654568 Free PMC article.
Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy.
Ray S, Paulmurugan R, Patel MR, Ahn BC, Wu L, Carey M, Gambhir SS. Ray S, et al. Mol Ther. 2008 Nov;16(11):1848-56. doi: 10.1038/mt.2008.180. Epub 2008 Sep 2. Mol Ther. 2008. PMID: 18766175 Free PMC article.
Compared to the one-step systems (Ad-pSurv-FL or Ad-pSurv-TR), the bidirectional TSTA system showed tenfold higher expression of both the therapeutic and the reporter gene and their expression correlated in cells (R(2) = 0.99) and in animals (R(2) = 0.67). ...
Compared to the one-step systems (Ad-pSurv-FL or Ad-pSurv-TR), the bidirectional TSTA system showed tenfold higher expression of both the th …
Theranostic Imaging of Cancer Gene Therapy.
Sekar TV, Paulmurugan R. Sekar TV, et al. Methods Mol Biol. 2016;1461:241-54. doi: 10.1007/978-1-4939-3813-1_20. Methods Mol Biol. 2016. PMID: 27424910
Imaging Histone Methylations in Living Animals.
Sekar TV, Paulmurugan R. Sekar TV, et al. Methods Mol Biol. 2016;1461:203-15. doi: 10.1007/978-1-4939-3813-1_17. Methods Mol Biol. 2016. PMID: 27424907
Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part I. Reporter Gene Design, Characterization, and Optical in Vivo Imaging of Bone Marrow Stromal Cells after Myocardial Infarction.
Parashurama N, Ahn BC, Ziv K, Ito K, Paulmurugan R, Willmann JK, Chung J, Ikeno F, Swanson JC, Merk DR, Lyons JK, Yerushalmi D, Teramoto T, Kosuge H, Dao CN, Ray P, Patel M, Chang YF, Mahmoudi M, Cohen JE, Goldstone AB, Habte F, Bhaumik S, Yaghoubi S, Robbins RC, Dash R, Yang PC, Brinton TJ, Yock PG, McConnell MV, Gambhir SS. Parashurama N, et al. Radiology. 2016 Sep;280(3):815-25. doi: 10.1148/radiol.2016140049. Epub 2016 Jun 16. Radiology. 2016. PMID: 27308957 Free PMC article.
Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression.
Ray S, Paulmurugan R, Hildebrandt I, Iyer M, Wu L, Carey M, Gambhir SS. Ray S, et al. Hum Gene Ther. 2004 Jul;15(7):681-90. doi: 10.1089/1043034041361271. Hum Gene Ther. 2004. PMID: 15242528 Free PMC article.
When mammalian cells were transiently cotransfected with the GAL4-responsive bidirectional reporter vector and various doses of the activator plasmid encoding the GAL4-VP16 fusion protein, pSV40-GAL4-VP16, a high correlation (r(2) = 0.95) was observed between the expressio …
When mammalian cells were transiently cotransfected with the GAL4-responsive bidirectional reporter vector and various doses of the activato …
143 results
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