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Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited.
Paumgartner G, Beuers U. Paumgartner G, et al. Hepatology. 2002 Sep;36(3):525-31. doi: 10.1053/jhep.2002.36088. Hepatology. 2002. PMID: 12198643 Review.
Experimental evidence suggests three major mechanisms of action: (1) protection of cholangiocytes against cytotoxicity of hydrophobic bile acids, resulting from modulation of the composition of mixed phospholipid-rich micelles, reduction of bile acid cytotoxicity of bile and, pos …
Experimental evidence suggests three major mechanisms of action: (1) protection of cholangiocytes against cytotoxicity of hydrophobic bile a …
Pharmacotherapy of cholestatic liver diseases.
Paumgartner G. Paumgartner G. J Dig Dis. 2010 Jun;11(3):119-25. doi: 10.1111/j.1751-2980.2010.00427.x. J Dig Dis. 2010. PMID: 20579215
Biliary physiology and disease: reflections of a physician-scientist.
Paumgartner G. Paumgartner G. Hepatology. 2010 Apr;51(4):1095-106. doi: 10.1002/hep.23472. Hepatology. 2010. PMID: 20373364 Review.
Does ursodeoxycholic acid change the proliferation of the colorectal mucosa?. A randomized, placebo-controlled study.
Ochsenkühn T, Marsteller I, Hay U, Diebold J, Paumgartner G, Göke B, Sackmann M. Ochsenkühn T, et al. Digestion. 2003;68(4):209-16. doi: 10.1159/000075927. Epub 2003 Dec 30. Digestion. 2003. PMID: 14707397 Clinical Trial.
Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets.
Beuers U, Denk GU, Soroka CJ, Wimmer R, Rust C, Paumgartner G, Boyer JL. Beuers U, et al. J Biol Chem. 2003 May 16;278(20):17810-8. doi: 10.1074/jbc.M209898200. Epub 2003 Mar 7. J Biol Chem. 2003. PMID: 12626520
Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells.
Glasova H, Berghaus TM, Kullak-Ublick GA, Paumgartner G, Beuers U. Glasova H, et al. Eur J Clin Invest. 2002 Jun;32(6):437-42. doi: 10.1046/j.1365-2362.2002.01002.x. Eur J Clin Invest. 2002. PMID: 12059989
Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.
Baghdasaryan A, Fuchs CD, Österreicher CH, Lemberger UJ, Halilbasic E, Påhlman I, Graffner H, Krones E, Fickert P, Wahlström A, Ståhlman M, Paumgartner G, Marschall HU, Trauner M. Baghdasaryan A, et al. Among authors: paumgartner g. J Hepatol. 2016 Mar;64(3):674-81. doi: 10.1016/j.jhep.2015.10.024. Epub 2015 Oct 31. J Hepatol. 2016. PMID: 26529078 Free article.
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