Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

80 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.
Pause A, Sonenberg N. Pause A, et al. EMBO J. 1992 Jul;11(7):2643-54. EMBO J. 1992. PMID: 1378397 Free PMC article.
This activity is thought to be responsible for the melting of secondary structure in the 5' untranslated region of eukaryotic mRNAs to facilitate ribosome binding. eIF-4A is a member of a fast growing family of proteins termed the DEAD family. ...Mutations in the AT …
This activity is thought to be responsible for the melting of secondary structure in the 5' untranslated region of eukaryotic mRNAs to facil …
Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication.
Welbourn S, Green R, Gamache I, Dandache S, Lohmann V, Bartenschlager R, Meerovitch K, Pause A. Welbourn S, et al. Among authors: pause a. J Biol Chem. 2005 Aug 19;280(33):29604-11. doi: 10.1074/jbc.M505019200. Epub 2005 Jun 24. J Biol Chem. 2005. PMID: 15980068
Interestingly, NS3 was still capable of efficient processing of the polyprotein expressed from a subgenomic replicon in Huh-7 cells in the presence of uncleaved NS2. ...Finally, we demonstrate that uncleaved NS2/3 degradation can be prevented by the addition of a pr …
Interestingly, NS3 was still capable of efficient processing of the polyprotein expressed from a subgenomic replicon in Huh-7 cells i …
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. Morita M, et al. Among authors: pause a. Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. Cell Metab. 2013. PMID: 24206664
Stimulating the translation of nucleus-encoded mitochondria-related mRNAs engenders an increase in ATP production capacity, a required energy source for translation. These findings establish a feed-forward loop that links mRNA translation to oxidative phosphorylatio …
Stimulating the translation of nucleus-encoded mitochondria-related mRNAs engenders an increase in ATP production capacity, a require …
The ever-evolving role of mTOR in translation.
Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A. Fonseca BD, et al. Among authors: pause a. Semin Cell Dev Biol. 2014 Dec;36:102-12. doi: 10.1016/j.semcdb.2014.09.014. Epub 2014 Sep 27. Semin Cell Dev Biol. 2014. PMID: 25263010 Review.
Perhaps most remarkably, mTOR is also a key regulator of the synthesis of ribosomal proteins and translation factors themselves. ...By controlling ribosome production (and ultimately ribosome availability), mTOR is a master long-term controller of protein synthesis. …
Perhaps most remarkably, mTOR is also a key regulator of the synthesis of ribosomal proteins and translation factors themselves. ...B …
Stress granules counteract senescence by sequestration of PAI-1.
Omer A, Patel D, Lian XJ, Sadek J, Di Marco S, Pause A, Gorospe M, Gallouzi IE. Omer A, et al. Among authors: pause a. EMBO Rep. 2018 May;19(5):e44722. doi: 10.15252/embr.201744722. Epub 2018 Mar 28. EMBO Rep. 2018. PMID: 29592859 Free PMC article.
The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.
Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE. Hall DT, et al. Among authors: pause a. EMBO Mol Med. 2018 Jul;10(7):e8307. doi: 10.15252/emmm.201708307. EMBO Mol Med. 2018. PMID: 29844217 Free PMC article.
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.
Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N. Dostie J, et al. Among authors: pause a. EMBO J. 2000 Jun 15;19(12):3142-56. doi: 10.1093/emboj/19.12.3142. EMBO J. 2000. PMID: 10856257 Free PMC article.
However, a fraction of eIF4E localizes to the nucleus. Here we describe the cloning and functional characterization of a new eIF4E-binding protein, referred to as 4E-T (eIF4E-Transporter). We demonstrate that 4E-T is a nucleocytoplasmic shuttling protein that …
However, a fraction of eIF4E localizes to the nucleus. Here we describe the cloning and functional characterization of a new e …
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.
Rousseau D, Gingras AC, Pause A, Sonenberg N. Rousseau D, et al. Among authors: pause a. Oncogene. 1996 Dec 5;13(11):2415-20. Oncogene. 1996. PMID: 8957083
The binding of the mRNA to the 40S ribosomal subunit, which is mediated by the mRNA cap structure, is a key target for control of protein synthesis. ...We propose that 4E-BPs are members of a class of negative regulators of cell growth acting on the translation mach …
The binding of the mRNA to the 40S ribosomal subunit, which is mediated by the mRNA cap structure, is a key target for control of pro …
La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA.
Svitkin YV, Pause A, Sonenberg N. Svitkin YV, et al. Among authors: pause a. J Virol. 1994 Nov;68(11):7001-7. doi: 10.1128/JVI.68.11.7001-7007.1994. J Virol. 1994. PMID: 7933082 Free PMC article.
The trans-activation response element (TAR) at the 5' end of the human immunodeficiency virus type 1 (HIV-1) mRNAs forms a stable hairpin structure which is a target for binding of the virally encoded protein Tat, which activates viral gene expression, as well as se …
The trans-activation response element (TAR) at the 5' end of the human immunodeficiency virus type 1 (HIV-1) mRNAs forms a stable hai …
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC Jr, Sonenberg N. Pause A, et al. Nature. 1994 Oct 27;371(6500):762-7. doi: 10.1038/371762a0. Nature. 1994. PMID: 7935836
80 results
Jump to page
Feedback