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An oxygen-regulated switch in the protein synthesis machinery.
Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S. Uniacke J, et al. Among authors: pause a. Nature. 2012 May 6;486(7401):126-9. doi: 10.1038/nature11055. Nature. 2012. PMID: 22678294 Free PMC article.
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. Morita M, et al. Among authors: pause a. Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. Cell Metab. 2013. PMID: 24206664
The ever-evolving role of mTOR in translation.
Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A. Fonseca BD, et al. Among authors: pause a. Semin Cell Dev Biol. 2014 Dec;36:102-12. doi: 10.1016/j.semcdb.2014.09.014. Epub 2014 Sep 27. Semin Cell Dev Biol. 2014. PMID: 25263010 Review.
Stress granules counteract senescence by sequestration of PAI-1.
Omer A, Patel D, Lian XJ, Sadek J, Di Marco S, Pause A, Gorospe M, Gallouzi IE. Omer A, et al. Among authors: pause a. EMBO Rep. 2018 May;19(5):e44722. doi: 10.15252/embr.201744722. Epub 2018 Mar 28. EMBO Rep. 2018. PMID: 29592859 Free PMC article.
The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.
Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE. Hall DT, et al. Among authors: pause a. EMBO Mol Med. 2018 Jul;10(7):e8307. doi: 10.15252/emmm.201708307. EMBO Mol Med. 2018. PMID: 29844217 Free PMC article.
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