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Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model.
Keelan JA, Kemp MW, Payne MS, Johnson D, Stock SJ, Saito M, Fernandes P, Newnham JP. Keelan JA, et al. Among authors: payne ms. Antimicrob Agents Chemother. 2014;58(1):447-54. doi: 10.1128/AAC.01743-13. Epub 2013 Nov 4. Antimicrob Agents Chemother. 2014. PMID: 24189250 Free PMC article.
Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection.
Miura Y, Payne MS, Keelan JA, Noe A, Carter S, Watts R, Spiller OB, Jobe AH, Kallapur SG, Saito M, Stock SJ, Newnham JP, Kemp MW. Miura Y, et al. Among authors: payne ms. Antimicrob Agents Chemother. 2014 Sep;58(9):5413-20. doi: 10.1128/AAC.03187-14. Epub 2014 Jun 30. Antimicrob Agents Chemother. 2014. PMID: 24982089 Free PMC article.
Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy.
Kemp MW, Miura Y, Payne MS, Jobe AH, Kallapur SG, Saito M, Stock SJ, Spiller OB, Ireland DJ, Yaegashi N, Clarke M, Hahne D, Rodger J, Keelan JA, Newnham JP. Kemp MW, et al. Among authors: payne ms. Antimicrob Agents Chemother. 2014 Nov;58(11):6581-91. doi: 10.1128/AAC.03721-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155606 Free PMC article.
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