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Structural biology of the S1P1 receptor.
Hanson MA, Peach R. Hanson MA, et al. Curr Top Microbiol Immunol. 2014;378:23-53. doi: 10.1007/978-3-319-05879-5_2. Curr Top Microbiol Immunol. 2014. PMID: 24728592 Review.
Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.
Karuppuchamy T, Behrens EH, González-Cabrera P, Sarkisyan G, Gima L, Boyer JD, Bamias G, Jedlicka P, Veny M, Clark D, Peach R, Scott F, Rosen H, Rivera-Nieves J. Karuppuchamy T, et al. Mucosal Immunol. 2017 Jan;10(1):162-171. doi: 10.1038/mi.2016.35. Epub 2016 Apr 6. Mucosal Immunol. 2017. PMID: 27049060 Free PMC article.
Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity.
Scott FL, Clemons B, Brooks J, Brahmachary E, Powell R, Dedman H, Desale HG, Timony GA, Martinborough E, Rosen H, Roberts E, Boehm MF, Peach RJ. Scott FL, et al. Among authors: peach rj. Br J Pharmacol. 2016 Jun;173(11):1778-92. doi: 10.1111/bph.13476. Epub 2016 Apr 28. Br J Pharmacol. 2016. PMID: 26990079 Free PMC article.
89 results