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Page 1
The nuts and bolts of AGC protein kinases.
Pearce LR, Komander D, Alessi DR. Pearce LR, et al. Nat Rev Mol Cell Biol. 2010 Jan;11(1):9-22. doi: 10.1038/nrm2822. Nat Rev Mol Cell Biol. 2010. PMID: 20027184 Review.
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR. Pearce LR, et al. Biochem J. 2011 May 15;436(1):169-79. doi: 10.1042/BJ20102103. Biochem J. 2011. PMID: 21413931
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).
Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR. Pearce LR, et al. Biochem J. 2010 Oct 15;431(2):245-55. doi: 10.1042/BJ20101024. Biochem J. 2010. PMID: 20704563
Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. Pearce LR, et al. Biochem J. 2007 Aug 1;405(3):513-22. doi: 10.1042/BJ20070540. Biochem J. 2007. PMID: 17461779 Free PMC article.
New insights into mTOR signaling: mTORC2 and beyond.
Alessi DR, Pearce LR, García-Martínez JM. Alessi DR, et al. Among authors: pearce lr. Sci Signal. 2009 Apr 21;2(67):pe27. doi: 10.1126/scisignal.267pe27. Sci Signal. 2009. PMID: 19383978
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.
Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ; UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS. Pearce LR, et al. Cell. 2013 Nov 7;155(4):765-77. doi: 10.1016/j.cell.2013.09.058. Cell. 2013. PMID: 24209692 Free PMC article.
Human SH2B1 mutations are associated with maladaptive behaviors and obesity.
Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi IS. Doche ME, et al. Among authors: pearce lr. J Clin Invest. 2012 Dec;122(12):4732-6. doi: 10.1172/JCI62696. Epub 2012 Nov 19. J Clin Invest. 2012. PMID: 23160192 Free PMC article.
Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.
Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C. Pearce LR, et al. Endocrinology. 2014 Sep;155(9):3219-26. doi: 10.1210/en.2014-1264. Epub 2014 Jun 27. Endocrinology. 2014. PMID: 24971614 Free PMC article.
A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity.
Borman AD, Pearce LR, Mackay DS, Nagel-Wolfrum K, Davidson AE, Henderson R, Garg S, Waseem NH, Webster AR, Plagnol V, Wolfrum U, Farooqi IS, Moore AT. Borman AD, et al. Among authors: pearce lr. Hum Mutat. 2014 Mar;35(3):289-93. doi: 10.1002/humu.22482. Epub 2013 Dec 20. Hum Mutat. 2014. PMID: 24375934 Free PMC article.
The man who mistook his neuropsychologist for a popstar: when configural processing fails in acquired prosopagnosia.
Jansari A, Miller S, Pearce L, Cobb S, Sagiv N, Williams AL, Tree JJ, Hanley JR. Jansari A, et al. Front Hum Neurosci. 2015 Jul 17;9:390. doi: 10.3389/fnhum.2015.00390. eCollection 2015. Front Hum Neurosci. 2015. PMID: 26236212 Free PMC article.