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Synthesis and activity of small molecule GPR40 agonists.
Garrido DM, Corbett DF, Dwornik KA, Goetz AS, Littleton TR, McKeown SC, Mills WY, Smalley TL Jr, Briscoe CP, Peat AJ. Garrido DM, et al. Among authors: peat aj. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1840-5. doi: 10.1016/j.bmcl.2006.01.007. Epub 2006 Jan 24. Bioorg Med Chem Lett. 2006. PMID: 16439116
Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3.
Smalley TL Jr, Peat AJ, Boucheron JA, Dickerson S, Garrido D, Preugschat F, Schweiker SL, Thomson SA, Wang TY. Smalley TL Jr, et al. Among authors: peat aj. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2091-4. doi: 10.1016/j.bmcl.2006.01.057. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16460937
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S. Briscoe CP, et al. Among authors: peat aj. Br J Pharmacol. 2006 Jul;148(5):619-28. doi: 10.1038/sj.bjp.0706770. Epub 2006 May 15. Br J Pharmacol. 2006. PMID: 16702987 Free PMC article.
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
Hertzog DL, Al-Barazanji KA, Bigham EC, Bishop MJ, Britt CS, Carlton DL, Cooper JP, Daniels AJ, Garrido DM, Goetz AS, Grizzle MK, Guo YC, Handlon AL, Ignar DM, Morgan RO, Peat AJ, Tavares FX, Zhou H. Hertzog DL, et al. Among authors: peat aj. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4723-7. doi: 10.1016/j.bmcl.2006.07.008. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870432
Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors.
Peat AJ, Boucheron JA, Dickerson SH, Garrido D, Mills W, Peckham J, Preugschat F, Smalley T, Schweiker SL, Wilson JR, Wang TY, Zhou HQ, Thomson SA. Peat AJ, et al. Bioorg Med Chem Lett. 2004 May 3;14(9):2121-5. doi: 10.1016/j.bmcl.2004.02.036. Bioorg Med Chem Lett. 2004. PMID: 15080992
Novel GSK-3 inhibitors with improved cellular activity.
Peat AJ, Garrido D, Boucheron JA, Schweiker SL, Dickerson SH, Wilson JR, Wang TY, Thomson SA. Peat AJ, et al. Bioorg Med Chem Lett. 2004 May 3;14(9):2127-30. doi: 10.1016/j.bmcl.2004.02.037. Bioorg Med Chem Lett. 2004. PMID: 15080993
26 results