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Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating.
Perl S, Kushner JA, Buchholz BA, Meeker AK, Stein GM, Hsieh M, Kirby M, Pechhold S, Liu EH, Harlan DM, Tisdale JF. Perl S, et al. Among authors: pechhold s. J Clin Endocrinol Metab. 2010 Oct;95(10):E234-9. doi: 10.1210/jc.2010-0932. Epub 2010 Jul 21. J Clin Endocrinol Metab. 2010. PMID: 20660050 Free PMC article.
Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells.
Lau-Kilby AW, Kretz CC, Pechhold S, Price JD, Dorta S, Ramos H, Trinchieri G, Tarbell KV. Lau-Kilby AW, et al. Among authors: pechhold s. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2408-13. doi: 10.1073/pnas.1009738108. Epub 2011 Jan 24. Proc Natl Acad Sci U S A. 2011. PMID: 21262836 Free PMC article.
The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells.
Liou AP, Sei Y, Zhao X, Feng J, Lu X, Thomas C, Pechhold S, Raybould HE, Wank SA. Liou AP, et al. Among authors: pechhold s. Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G538-46. doi: 10.1152/ajpgi.00342.2010. Epub 2011 Jan 20. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21252045 Free PMC article.
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Shmuel-Galia L, et al. Among authors: pechhold s. Immunity. 2021 Jun 8;54(6):1137-1153.e8. doi: 10.1016/j.immuni.2021.05.008. Epub 2021 May 28. Immunity. 2021. PMID: 34051146 Free PMC article.