Pedersen DV - Search Results

1

Functional and structural insight into properdin control of complement alternative pathway amplification.

Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, Marinozzi C, Picard C, Rybkine T, Thiel S, Sørensen UB, Stover C, Fremeaux-Bacchi V, Andersen GR. Pedersen DV, et al. EMBO J. 2017 Apr 13;36(8):1084-1099. doi: 10.15252/embj.201696173. Epub 2017 Mar 6. EMBO J. 2017. PMID: 28264884 Free PMC article.

2

Structural insight into proteolytic activation and regulation of the complement system.

Schatz-Jakobsen JA, Pedersen DV, Andersen GR. Schatz-Jakobsen JA, et al. Among authors: pedersen dv. Immunol Rev. 2016 Nov;274(1):59-73. doi: 10.1111/imr.12465. Immunol Rev. 2016. PMID: 27782336 Review.

3

Crystallization and X-ray analysis of monodisperse human properdin.

Pedersen DV, Revel M, Gadeberg TAF, Andersen GR. Pedersen DV, et al. Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):0. doi: 10.1107/S2053230X18018150. Epub 2019 Jan 23. Acta Crystallogr F Struct Biol Commun. 2019. PMID: 30713161 Free PMC article.

4

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.

Pedersen DV, Gadeberg TAF, Thomas C, Wang Y, Joram N, Jensen RK, Mazarakis SMM, Revel M, El Sissy C, Petersen SV, Lindorff-Larsen K, Thiel S, Laursen NS, Fremeaux-Bacchi V, Andersen GR. Pedersen DV, et al. Front Immunol. 2019 Aug 22;10:2007. doi: 10.3389/fimmu.2019.02007. eCollection 2019. Front Immunol. 2019. PMID: 31507604 Free PMC article.

5

Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement.

Pedersen DV, Rösner T, Hansen AG, Andersen KR, Thiel S, Andersen GR, Valerius T, Laursen NS. Pedersen DV, et al. Mol Immunol. 2020 Aug;124:200-210. doi: 10.1016/j.molimm.2020.06.005. Epub 2020 Jun 26. Mol Immunol. 2020. PMID: 32599335

6

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.

Laursen NS, Pedersen DV, Gytz H, Zarantonello A, Bernth Jensen JM, Hansen AG, Thiel S, Andersen GR. Laursen NS, et al. Among authors: pedersen dv. Front Immunol. 2020 Jul 17;11:1504. doi: 10.3389/fimmu.2020.01504. eCollection 2020. Front Immunol. 2020. PMID: 32849513 Free PMC article.

7

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement.

Zhang J, Song L, Pedersen DV, Li A, Lambris JD, Andersen GR, Mollnes TE, Ma YJ, Garred P. Zhang J, et al. Among authors: pedersen dv. Elife. 2020 Sep 10;9:e60908. doi: 10.7554/eLife.60908. Elife. 2020. PMID: 32909942 Free PMC article.

8

A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.

Pedersen H, Jensen RK, Jensen JMB, Fox R, Pedersen DV, Olesen HG, Hansen AG, Christiansen D, Mazarakis SMM, Lojek N, Hansen P, Gadeberg TAF, Zarantonello A, Laursen NS, Mollnes TE, Johnson MB, Stevens B, Thiel S, Andersen GR. Pedersen H, et al. Among authors: pedersen dv. J Immunol. 2020 Oct 15;205(8):2287-2300. doi: 10.4049/jimmunol.2000752. Epub 2020 Sep 16. J Immunol. 2020. PMID: 32938727

9

Properdin oligomers adopt rigid extended conformations supporting function.

Pedersen DV, Pedersen MN, Mazarakis SM, Wang Y, Lindorff-Larsen K, Arleth L, Andersen GR. Pedersen DV, et al. Elife. 2021 Jan 22;10:e63356. doi: 10.7554/eLife.63356. Elife. 2021. PMID: 33480354 Free PMC article.

10

Structure and function of a family of tick-derived complement inhibitors targeting properdin.

Braunger K, Ahn J, Jore MM, Johnson S, Tang TTL, Pedersen DV, Andersen GR, Lea SM. Braunger K, et al. Among authors: pedersen dv. Nat Commun. 2022 Jan 14;13(1):317. doi: 10.1038/s41467-021-27920-2. Nat Commun. 2022. PMID: 35031611 Free PMC article.

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