Pedley AM - Search Results

1

A New View into the Regulation of Purine Metabolism: The Purinosome.

Pedley AM, Benkovic SJ. Pedley AM, et al. Trends Biochem Sci. 2017 Feb;42(2):141-154. doi: 10.1016/j.tibs.2016.09.009. Epub 2016 Oct 28. Trends Biochem Sci. 2017. PMID: 28029518 Free PMC article. Review.

2

Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis.

Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ. Zhao H, et al. Among authors: pedley am. J Biol Chem. 2015 Mar 13;290(11):6705-13. doi: 10.1074/jbc.M114.628701. Epub 2015 Jan 20. J Biol Chem. 2015. PMID: 25605736 Free PMC article.

3

Purinosome formation as a function of the cell cycle.

Chan CY, Zhao H, Pugh RJ, Pedley AM, French J, Jones SA, Zhuang X, Jinnah H, Huang TJ, Benkovic SJ. Chan CY, et al. Among authors: pedley am. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1368-73. doi: 10.1073/pnas.1423009112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605889 Free PMC article.

4

Spatial colocalization and functional link of purinosomes with mitochondria.

French JB, Jones SA, Deng H, Pedley AM, Kim D, Chan CY, Hu H, Pugh RJ, Zhao H, Zhang Y, Huang TJ, Fang Y, Zhuang X, Benkovic SJ. French JB, et al. Among authors: pedley am. Science. 2016 Feb 12;351(6274):733-7. doi: 10.1126/science.aac6054. Science. 2016. PMID: 26912862 Free PMC article.

5

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.

Pedley AM, Karras GI, Zhang X, Lindquist S, Benkovic SJ. Pedley AM, et al. Biochemistry. 2018 Jun 12;57(23):3217-3221. doi: 10.1021/acs.biochem.8b00140. Epub 2018 Mar 23. Biochemistry. 2018. PMID: 29553718 Free PMC article.

6

Detecting Purinosome Metabolon Formation with Fluorescence Microscopy.

Pedley AM, Benkovic SJ. Pedley AM, et al. Methods Mol Biol. 2018;1764:279-289. doi: 10.1007/978-1-4939-7759-8_17. Methods Mol Biol. 2018. PMID: 29605921 Free PMC article.

7

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria.

Chan CY, Pedley AM, Kim D, Xia C, Zhuang X, Benkovic SJ. Chan CY, et al. Among authors: pedley am. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13009-13014. doi: 10.1073/pnas.1814042115. Epub 2018 Dec 3. Proc Natl Acad Sci U S A. 2018. PMID: 30509995 Free PMC article.

8

Hypoxia drives the assembly of the multienzyme purinosome complex.

Doigneaux C, Pedley AM, Mistry IN, Papayova M, Benkovic SJ, Tavassoli A. Doigneaux C, et al. Among authors: pedley am. J Biol Chem. 2020 Jul 10;295(28):9551-9566. doi: 10.1074/jbc.RA119.012175. Epub 2020 May 21. J Biol Chem. 2020. PMID: 32439803 Free PMC article.

9

Human de novo purine biosynthesis.

Pareek V, Pedley AM, Benkovic SJ. Pareek V, et al. Among authors: pedley am. Crit Rev Biochem Mol Biol. 2021 Feb;56(1):1-16. doi: 10.1080/10409238.2020.1832438. Epub 2020 Nov 12. Crit Rev Biochem Mol Biol. 2021. PMID: 33179964

10

Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen.

Hedglin M, Aitha M, Pedley A, Benkovic SJ. Hedglin M, et al. J Biol Chem. 2019 Mar 29;294(13):5157-5168. doi: 10.1074/jbc.RA118.005297. Epub 2019 Jan 30. J Biol Chem. 2019. PMID: 30700555 Free PMC article.

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