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Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis.
Al-Izki S, Pryce G, Hankey DJ, Lidster K, von Kutzleben SM, Browne L, Clutterbuck L, Posada C, Edith Chan AW, Amor S, Perkins V, Gerritsen WH, Ummenthum K, Peferoen-Baert R, van der Valk P, Montoya A, Joel SP, Garthwaite J, Giovannoni G, Selwood DL, Baker D. Al-Izki S, et al. Among authors: peferoen baert r. Brain. 2014 Jan;137(Pt 1):92-108. doi: 10.1093/brain/awt324. Epub 2013 Nov 27. Brain. 2014. PMID: 24287115
Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease.
Ummenthum K, Peferoen LA, Finardi A, Baker D, Pryce G, Mantovani A, Bsibsi M, Bottazzi B, Peferoen-Baert R, van der Valk P, Garlanda C, Kipp M, Furlan R, van Noort JM, Amor S. Ummenthum K, et al. Among authors: peferoen baert r. Eur J Immunol. 2016 Mar;46(3):701-11. doi: 10.1002/eji.201545950. Epub 2015 Dec 14. Eur J Immunol. 2016. PMID: 26576501 Free article.
Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis.
Peferoen LA, Lamers F, Lodder LN, Gerritsen WH, Huitinga I, Melief J, Giovannoni G, Meier U, Hintzen RQ, Verjans GM, van Nierop GP, Vos W, Peferoen-Baert RM, Middeldorp JM, van der Valk P, Amor S. Peferoen LA, et al. Among authors: peferoen baert rm. Brain. 2010 May;133(Pt 5):e137. doi: 10.1093/brain/awp296. Epub 2009 Nov 16. Brain. 2010. PMID: 19917644 No abstract available.
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation.
van Horssen J, Singh S, van der Pol S, Kipp M, Lim JL, Peferoen L, Gerritsen W, Kooi EJ, Witte ME, Geurts JJ, de Vries HE, Peferoen-Baert R, van den Elsen PJ, van der Valk P, Amor S. van Horssen J, et al. Among authors: peferoen baert r. J Neuroinflammation. 2012 Jul 2;9:156. doi: 10.1186/1742-2094-9-156. J Neuroinflammation. 2012. PMID: 22747960 Free PMC article.
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Miedema A, Gerrits E, Brouwer N, Jiang Q, Kracht L, Meijer M, Nutma E, Peferoen-Baert R, Pijnacker ATE, Wesseling EM, Wijering MHC, Gabius HJ, Amor S, Eggen BJL, Kooistra SM. Miedema A, et al. Among authors: peferoen baert r. Acta Neuropathol Commun. 2022 Jan 28;10(1):8. doi: 10.1186/s40478-021-01306-3. Acta Neuropathol Commun. 2022. PMID: 35090578 Free PMC article.