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Pegloticase.
[No authors listed] [No authors listed] 2023 Nov 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2023 Nov 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 34406723 Free Books & Documents. Review.
No information is available on the use of pegloticase during breastfeeding. Because pegloticase is a very large molecule with molecular weight of 540,000 Da, and composed of smaller subunits with molecular weights of 34,000 Da, the amount in milk is likely to be ver …
No information is available on the use of pegloticase during breastfeeding. Because pegloticase is a very large molecule with …
Pegloticase treatment of chronic refractory gout: Update on efficacy and safety.
Schlesinger N, Lipsky PE. Schlesinger N, et al. Semin Arthritis Rheum. 2020 Jun;50(3S):S31-S38. doi: 10.1016/j.semarthrit.2020.04.011. Semin Arthritis Rheum. 2020. PMID: 32620200 Free article. Review.
Pegloticase is different than other urate lowering therapies in that it enzymatically degrades urate. ...However, these reactions can be avoided by stopping pegloticase when there is a loss of serum urate lowering. New dosing regimens and co-administration of immuno …
Pegloticase is different than other urate lowering therapies in that it enzymatically degrades urate. ...However, these reactions can …
Pegloticase Therapy and G6PD Genotype.
Dean L, Kane M. Dean L, et al. 2020 Oct 1. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2020 Oct 1. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 33001605 Free Books & Documents. Review.
Pegloticase (brand name Krystexxa) is used to treat the high levels of uric acid associated with refractory gout. ...However, they are at risk of life-threating hemolytic reactions and methemoglobinemia if given oxidizing drugs such as pegloticase. Pegloticase …
Pegloticase (brand name Krystexxa) is used to treat the high levels of uric acid associated with refractory gout. ...However, they ar …
Pegloticase.
Padda IS, Bhatt R, Patel P, Parmar M. Padda IS, et al. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 34283420 Free Books & Documents.
Pegloticase, an FDA-approved pegylated, recombinant uricase, helps manage chronic gout refractory to standard therapy among adult patients. ...Attendees will become more knowledgeable about pegloticase therapy, including its adverse event profile, enabling interprof …
Pegloticase, an FDA-approved pegylated, recombinant uricase, helps manage chronic gout refractory to standard therapy among adult pat …
A Randomized, Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings.
Botson JK, Saag K, Peterson J, Parikh N, Ong S, La D, LoCicero K, Obermeyer K, Xin Y, Chamberlain J, LaMoreaux B, Verma S, Sainati S, Grewal S, Majjhoo A, Tesser JRP, Weinblatt ME. Botson JK, et al. Arthritis Rheumatol. 2023 Feb;75(2):293-304. doi: 10.1002/art.42335. Epub 2022 Dec 16. Arthritis Rheumatol. 2023. PMID: 36099211 Free PMC article. Clinical Trial.
OBJECTIVE: To assess efficacy, safety, pharmacokinetics, and immunogenicity of pegloticase plus methotrexate (MTX) versus pegloticase plus placebo cotreatment for uncontrolled gout in a randomized, placebo-controlled, double-blind trial. ...During the first 6 months …
OBJECTIVE: To assess efficacy, safety, pharmacokinetics, and immunogenicity of pegloticase plus methotrexate (MTX) versus peglotic …
Pegloticase.
[No authors listed] [No authors listed] 2018 May 21. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2018 May 21. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644077 Free Books & Documents. Review.
Pegloticase is a pegylated, recombinant urate oxidase enzyme that is used to treat patients with chronic refractory and symptomatic gout. Pegloticase has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver i …
Pegloticase is a pegylated, recombinant urate oxidase enzyme that is used to treat patients with chronic refractory and symptomatic g …
Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials.
Sundy JS, Baraf HS, Yood RA, Edwards NL, Gutierrez-Urena SR, Treadwell EL, Vázquez-Mellado J, White WB, Lipsky PE, Horowitz Z, Huang W, Maroli AN, Waltrip RW 2nd, Hamburger SA, Becker MA. Sundy JS, et al. JAMA. 2011 Aug 17;306(7):711-20. doi: 10.1001/jama.2011.1169. JAMA. 2011. PMID: 21846852 Clinical Trial.
INTERVENTION: Twelve biweekly intravenous infusions containing either pegloticase 8 mg at each infusion (biweekly treatment group), pegloticase alternating with placebo at successive infusions (monthly treatment group), or placebo (placebo group). ...Seven deaths (4 …
INTERVENTION: Twelve biweekly intravenous infusions containing either pegloticase 8 mg at each infusion (biweekly treatment group), …
The effect of immunomodulators on the efficacy and tolerability of pegloticase: a systematic review.
Keenan RT, Botson JK, Masri KR, Padnick-Silver L, LaMoreaux B, Albert JA, Pillinger MH. Keenan RT, et al. Semin Arthritis Rheum. 2021 Apr;51(2):347-352. doi: 10.1016/j.semarthrit.2021.01.005. Epub 2021 Jan 27. Semin Arthritis Rheum. 2021. PMID: 33601190 Free article.
Duplicate and review articles were excluded, as were those that did not include cases of pegloticase use with immunomodulation. Cases with off-label pegloticase administration schedules were also excluded. Pegloticase response was defined according to each st …
Duplicate and review articles were excluded, as were those that did not include cases of pegloticase use with immunomodulation. Cases …
Pegloticase in gout treatment - safety issues, latest evidence and clinical considerations.
Guttmann A, Krasnokutsky S, Pillinger MH, Berhanu A. Guttmann A, et al. Ther Adv Drug Saf. 2017 Dec;8(12):379-388. doi: 10.1177/2042098617727714. Epub 2017 Sep 13. Ther Adv Drug Saf. 2017. PMID: 29204266 Free PMC article. Review.
Unfortunately, a proportion of patients have persistent gout that is refractory to ULT. Pegloticase, a recombinant pegylated uricase, has been approved by the US Food and Drug Administration for the treatment of refractory gout. ...In this manuscript, we review the rationa …
Unfortunately, a proportion of patients have persistent gout that is refractory to ULT. Pegloticase, a recombinant pegylated uricase, …
Pegloticase-Associated Hemolysis.
Minshar MA, Osman-Malik Y, Bhat ZY. Minshar MA, et al. Am J Ther. 2019 Sep/Oct;26(5):e622-e624. doi: 10.1097/MJT.0000000000000828. Am J Ther. 2019. PMID: 30211701 No abstract available.
227 results