Abstract
The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria(L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 µg) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism*
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Ascomycota / chemistry*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / pharmacology*
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Depsides / chemistry
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Depsides / isolation & purification
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Depsides / pharmacology*
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Enzyme Activation / drug effects
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Molecular Structure
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Structure-Activity Relationship
Substances
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Cholinesterase Inhibitors
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Depsides
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Lactones
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depsidone
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Acetylcholinesterase