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Prevalence of increased osmotic fragility of erythrocytes in German blood donors: screening using a modified glycerol lysis test.
Eber SW, Pekrun A, Neufeldt A, Schröter W. Eber SW, et al. Among authors: pekrun a. Ann Hematol. 1992 Feb;64(2):88-92. doi: 10.1007/BF01715351. Ann Hematol. 1992. PMID: 1554800
Further hematologic data showed a mild reticulocytosis (2% and 2.6%) in two of the donors. One donor had a moderate reticulocytosis of 6.5%, probably due to a mild, previously undiagnosed spherocytosis; 99 of the donors had an intermediate result (AGLT 50: 5- …
Further hematologic data showed a mild reticulocytosis (2% and 2.6%) in two of the donors. One donor had a moderate reticulocy …
Moyamoya syndrome associated with hemolytic anemia due to Hb Alesha.
Brockmann K, Stolpe S, Fels C, Khan N, Kulozik AE, Pekrun A. Brockmann K, et al. Among authors: pekrun a. J Pediatr Hematol Oncol. 2005 Aug;27(8):436-40. doi: 10.1097/01.mph.0000175409.21342.ea. J Pediatr Hematol Oncol. 2005. PMID: 16096527
The authors describe a previously unreported association of hemolytic anemia due to a rare unstable hemoglobinopathy with abnormal oxygen affinity (Hb Alesha) and moyamoya syndrome in a 10-year-old girl. ...Deterioration of her neurologic symptoms prompted …
The authors describe a previously unreported association of hemolytic anemia due to a rare unstable hemoglobinopathy with abno …
Cryohemolysis test as a diagnostic tool for hereditary spherocytosis.
Iglauer A, Reinhardt D, Schröter W, Pekrun A. Iglauer A, et al. Among authors: pekrun a. Ann Hematol. 1999 Dec;78(12):555-7. doi: 10.1007/s002770050557. Ann Hematol. 1999. PMID: 10647879
The cryohemolysis test has been proposed as a new method of identifying hereditary spherocytosis. The purpose of the present study was to analyze the sensitivity and specificity of this method in comparison to the measurement of osmotic fragility. ...It is concluded that t …
The cryohemolysis test has been proposed as a new method of identifying hereditary spherocytosis. The purpose of the present study wa …
Combined ankyrin and spectrin deficiency in hereditary spherocytosis.
Pekrun A, Eber SW, Kuhlmey A, Schröter W. Pekrun A, et al. Ann Hematol. 1993 Aug;67(2):89-93. doi: 10.1007/BF01788132. Ann Hematol. 1993. PMID: 8347735
Hereditary spherocytosis is characterized by a reduced spectrin content of the erythrocytes. However, the underlying primary defect remains unclear in the majority of cases. ...In contrast, 29 patients with moderate spherocytosis exhibited a clear reduction of both …
Hereditary spherocytosis is characterized by a reduced spectrin content of the erythrocytes. However, the underlying primary defect r …
Mutations in the R-type pyruvate kinase gene and altered enzyme kinetic properties in patients with hemolytic anemia due to pyruvate kinase deficiency.
Lakomek M, Huppke P, Neubauer B, Pekrun A, Winkler H, Schröter W. Lakomek M, et al. Among authors: pekrun a. Ann Hematol. 1994 Nov;69(5):253-60. doi: 10.1007/BF01700280. Ann Hematol. 1994. PMID: 7948315
In one allele of PK 'Bukarest' a single nucleotide substitution GAG-TAG was found at nucleotide 721, causing a change of 241 Glu to a chain termination codon (PK 'Bukarest'). ...A point mutation at position 1529 (CGA-CAA), causing an amino acid substit …
In one allele of PK 'Bukarest' a single nucleotide substitution GAG-TAG was found at nucleotide 721, causing a change of 241 G …
Triosephosphate isomerase deficiency: haemolytic anaemia, myopathy with altered mitochondria and mental retardation due to a new variant with accelerated enzyme catabolism and diminished specific activity.
Eber SW, Pekrun A, Bardosi A, Gahr M, Krietsch WK, Krüger J, Matthei R, Schröter W. Eber SW, et al. Among authors: pekrun a. Eur J Pediatr. 1991 Sep;150(11):761-6. doi: 10.1007/BF02026706. Eur J Pediatr. 1991. PMID: 1959537
A prevalent alteration of mitochondria similar to that seen in mitochondrial myopathy and an elevated amount of intracellular glycogen were found. ...The findings indicate that the low TPI activity leads to a metabolic block of the glycolytic pathway and hence to
A prevalent alteration of mitochondria similar to that seen in mitochondrial myopathy and an elevated amount of intracellular glycoge
[Aplastic crises in hereditary spherocytosis].
Pekrun A, Eiffert H, Eber SW, Schröter W. Pekrun A, et al. Monatsschr Kinderheilkd. 1988 Apr;136(4):173-5. Monatsschr Kinderheilkd. 1988. PMID: 2838746 German.
In addition to erythema infectiosum they cause a temporary red cell aplasia of 5-10 days duration, in patients with hemolytic anemia an aplastic crisis as demonstrated in 5 patients with hereditary spherocytosis. ...In every case there followed a complete recovery o …
In addition to erythema infectiosum they cause a temporary red cell aplasia of 5-10 days duration, in patients with hemolytic anemia …
The gamma-chain heterogeneity of haemoglobin F in German infants.
Pekrun A, Scharnetzky M, Gahr M, Schröter W. Pekrun A, et al. Eur J Pediatr. 1989 Jan;148(4):304-6. doi: 10.1007/BF00444119. Eur J Pediatr. 1989. PMID: 2468496
The A gamma T-gene frequency calculated was about 19%. In most cases with A gamma I-/A gamma T-chain heterogeneity A gamma I-chains predominated over A gamma T-chains. There was no difference between infants with or without the A gamma T- …
The A gamma T-gene frequency calculated was about 19%. In most cases with A gamma I-/A gamma T-chain heterogeneity A
Tributyrin plus all-trans-retinoic acid efficiently induces fetal hemoglobin expression in human erythroleukemia cells.
Witt O, Schmejkal S, Pekrun A. Witt O, et al. Among authors: pekrun a. Am J Hematol. 2000 Aug;64(4):319-21. doi: 10.1002/1096-8652(200008)64:4<319::aid-ajh16>3.0.co;2-d. Am J Hematol. 2000. PMID: 10911389
Fourteen butyrate derivatives and retinoic acid were tested with respect to the hemoglobin F-inducing activity using the K562 erythroleukemia cell line as a model system. ...Combined treatment with the butyrate derivative tributyrin and retinoic acid in vitro led to a
Fourteen butyrate derivatives and retinoic acid were tested with respect to the hemoglobin F-inducing activity using the K562 erythroleukemi …
Hemoglobin F in myelodysplastic syndrome.
Reinhardt D, Haase D, Schoch C, Wollenweber S, Hinkelmann E, v Heyden W, Lentini G, Wörmann B, Schröter W, Pekrun A. Reinhardt D, et al. Among authors: pekrun a. Ann Hematol. 1998 Mar-Apr;76(3-4):135-8. doi: 10.1007/s002770050377. Ann Hematol. 1998. PMID: 9619730
The Ggamma/Ggamma + A gamma-globin chain ratio was slightly elevated in all patients, with a weak correlation to the degree of hemoglobin F elevation. ...The data of the present study suggest that the hemoglobin F concentration may be a prognostic parameter i …
The Ggamma/Ggamma + A gamma-globin chain ratio was slightly elevated in all patients, with a weak correlation to the degree of …
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