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Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.
Pelletier H, Sawaya MR. Pelletier H, et al. Biochemistry. 1996 Oct 1;35(39):12778-87. doi: 10.1021/bi960790i. Biochemistry. 1996. PMID: 8841120
X-ray crystallographic studies have shown that DNA binding by human polymerase beta (pol beta) occurs primarily through two structurally and sequentially homologous helix-hairpin-helix (HhH) motifs, one in the fingers subdomain and the other in the 8-kDa domain [Pelletier, …
X-ray crystallographic studies have shown that DNA binding by human polymerase beta (pol beta) occurs primarily through two structurally and …
Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity.
Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J. Pelletier H, et al. Biochemistry. 1996 Oct 1;35(39):12742-61. doi: 10.1021/bi952955d. Biochemistry. 1996. PMID: 8841118
In the work reported here, crystal structures of human pol beta complexed with blunt-ended segments of DNA show that, although the crystals belong to a different space group, the DNA is nevertheless bound in the pol beta binding channel in the same way as the DNA in previously re …
In the work reported here, crystal structures of human pol beta complexed with blunt-ended segments of DNA show that, although the crystals …
A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta.
Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J. Pelletier H, et al. Biochemistry. 1996 Oct 1;35(39):12762-77. doi: 10.1021/bi9529566. Biochemistry. 1996. PMID: 8841119
When crystals of human DNA polymerase beta (pol beta) complexed with DNA [Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. H., & Kraut, J. (1996) Biochemistry 35, 12742-12761] are soaked in the presence of dATP and Mn2+, X-ray structural analysis show …
When crystals of human DNA polymerase beta (pol beta) complexed with DNA [Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. …
Crystallization of fragment D from human fibrinogen.
Everse SJ, Pelletier H, Doolittle RF. Everse SJ, et al. Among authors: pelletier h. Protein Sci. 1995 May;4(5):1013-6. doi: 10.1002/pro.5560040523. Protein Sci. 1995. PMID: 7663337 Free PMC article.
Polymerase structures and mechanism.
Pelletier H. Pelletier H. Science. 1994 Dec 23;266(5193):2025-6. doi: 10.1126/science.7801132. Science. 1994. PMID: 7801132 No abstract available.
55 results