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The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells.
Kwan Tat S, Pelletier JP, Lajeunesse D, Fahmi H, Lavigne M, Martel-Pelletier J. Kwan Tat S, et al. Among authors: pelletier jp. Clin Exp Rheumatol. 2008 Mar-Apr;26(2):295-304. Clin Exp Rheumatol. 2008. PMID: 18565252 Free PMC article.
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Boileau C, Pelletier JP, Tardif G, Fahmi H, Laufer S, Lavigne M, Martel-Pelletier J. Boileau C, et al. Among authors: pelletier jp. Ann Rheum Dis. 2005 Jun;64(6):891-8. doi: 10.1136/ard.2004.026906. Epub 2004 Oct 21. Ann Rheum Dis. 2005. PMID: 15498796 Free PMC article.
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